DegronMD - Q9Y4F5(CEP170B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A127V	TCGA-2W-A8YY	CESC	TCGA	PEHTPYCE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.1111
p.A127V	DO223732	CESC	ICGC	PEHTPYCE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.1111
p.F408L	TCGA-AJ-A5DW	UCEC	TCGA	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	409:416	Mutation rewiring degron network	0.3056
p.E1290G	TCGA-B5-A1MW	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation altering degron motif	0.7199
p.R415Q	TCGA-BR-7707	STAD	TCGA	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	409:416	Mutation altering degron motif	0.6218
p.R415Q	TCGA-E6-A1LX	UCEC	TCGA	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	409:416	Mutation altering degron motif	0.6218
p.R415Q	TCGA-EO-A22X	UCEC	TCGA	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	409:416	Mutation altering degron motif	0.6218
p.V1283M	TCGA-BR-8591	STAD	TCGA	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation rewiring degron network	0.1944
p.P146H	TCGA-D3-A3CB	SKCM	TCGA	PEHTPYCE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.2222
p.P146H	DO47386	SKCM	ICGC	PEHTPYCE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.2222
p.E1290D	TCGA-D9-A4Z3	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation altering degron motif	0.6758
p.E1290D	DO47555	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation altering degron motif	0.6758
p.P1278H	TCGA-DU-7294	LGG	TCGA	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation rewiring degron network	0.0556
p.P426L	TCGA-EI-6882	READ	TCGA	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	409:416	Mutation rewiring degron network	0.0556
p.R418C	TCGA-PK-A5HB	ACC	TCGA	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	409:416	Mutation rewiring degron network	0.2778
p.F404L	TCGA-PL-A8LY	BRCA	TCGA	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	409:416	Mutation rewiring degron network	0.1944
p.F404L	DO51217	BRCA	ICGC	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	409:416	Mutation rewiring degron network	0.1944
p.A1382T	TCGA-UF-A71B	HNSC	TCGA	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation rewiring degron network	0.1389
p.A1382T	SIDM00602	Gastric Carcinoma	GDSC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation rewiring degron network	0.1389
p.A1382T	SIDM01445	Gastric Carcinoma	GDSC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation rewiring degron network	0.1389
p.A1382T	ACH-000736	Gastric Cancer	CCLE	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation rewiring degron network	0.1389
p.A1382T	ACH-000919	Gastric Cancer	CCLE	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation rewiring degron network	0.1389
p.A1382T	IM-95	stomach	COSMIC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation rewiring degron network	0.1389
p.P1370L	DO3317	BRCA	ICGC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation altering degron motif	0.7582
p.A536T	DO10140	COAD	ICGC	PLTPHGT	DEG_SCF_FBW7_1	529:535	Mutation blocking phosphorylation signal	0.75
p.R697C	DO228119	EOPC	ICGC	MRRRLPQLP	DEG_APCC_DBOX_1	697:705	Mutation altering degron motif	0.8301
p.A1295S	DO228974	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation rewiring degron network	0.25
p.A1374S	DO228976	LICA	ICGC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation altering degron motif	0.7588
p.A1374S	DO229015	LICA	ICGC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation altering degron motif	0.7588
p.R1296L	DO228978	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation blocking phosphorylation signal	0.6667
p.R1296L	DO229019	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation blocking phosphorylation signal	0.6667
p.A1289S	DO229019	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation altering degron motif	0.7588
p.I1281F	DO229044	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation rewiring degron network	0.1389
p.R699W	DO50898	LICA	ICGC	MRRRLPQLP	DEG_APCC_DBOX_1	697:705	Mutation altering degron motif	0.7523
p.R699W	DO46877	RECA	ICGC	MRRRLPQLP	DEG_APCC_DBOX_1	697:705	Mutation altering degron motif	0.7523
p.V1299L	DO50832	LIRI	ICGC	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation rewiring degron network	0.1389
p.R1294Q	DO223718	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation rewiring degron network	0.2778
p.L1367V	DO27468	LUSC	ICGC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation rewiring degron network	0.3056
p.P703S	DO222875	MELA	ICGC	MRRRLPQLP	DEG_APCC_DBOX_1	697:705	Mutation altering degron motif	0.6752
p.R1126W	DO50726	ORCA	ICGC	LSTPRPT	DEG_SCF_FBW7_1	1115:1121	Mutation rewiring degron network	0.1944
p.E521K	DO35083	PACA	ICGC	PLTPHGT	DEG_SCF_FBW7_1	529:535	Mutation substituting flanking lysine	0.2222
p.N1385K	DO231284	PACA	ICGC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation rewiring degron network	0.0556
p.R426H	DO232761	PBCA	ICGC	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	409:416	Mutation rewiring degron network	0.0556
p.T1111P	DO219881	SKCA	ICGC	LSTPRPT	DEG_SCF_FBW7_1	1115:1121	Mutation rewiring degron network	0.2222
p.S693A	DO219876	SKCA	ICGC	MRRRLPQLP	DEG_APCC_DBOX_1	697:705	Mutation rewiring degron network	0.2222
p.S693A	DO218910	SKCA	ICGC	MRRRLPQLP	DEG_APCC_DBOX_1	697:705	Mutation rewiring degron network	0.2222
p.S693A	DO229084	THCA	ICGC	MRRRLPQLP	DEG_APCC_DBOX_1	697:705	Mutation rewiring degron network	0.2222
p.P706S	DO229502	SKCA	ICGC	MRRRLPQLP	DEG_APCC_DBOX_1	697:705	Mutation blocking phosphorylation signal	0.75
p.V1377L	DO37711	SKCM	ICGC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation rewiring degron network	0.2778
p.R1380L	DO37794	SKCM	ICGC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation rewiring degron network	0.1944
p.P1287T	DO47491	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation rewiring degron network	0.3056
p.S1291G	DO47380	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation altering degron motif	0.6993
p.R139G	DO38069	SKCM	ICGC	PEHTPYCE	DEG_SCF_FBW7_2	135:142	Mutation altering degron motif	0.7568
p.R416Q	DO38487	STAD	ICGC	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	409:416	Mutation altering degron motif	0.7329
p.R416Q	DO41020	UCEC	ICGC	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	409:416	Mutation altering degron motif	0.7329
p.R416Q	DO43907	UCEC	ICGC	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	409:416	Mutation altering degron motif	0.7329
p.R713W	DO38723	STAD	ICGC	MRRRLPQLP	DEG_APCC_DBOX_1	697:705	Mutation rewiring degron network	0.1111
p.D152G	DO229253	THCA	ICGC	PEHTPYCE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.0556
p.P542L	DO229268	THCA	ICGC	PLTPHGT	DEG_SCF_FBW7_1	529:535	Mutation blocking phosphorylation signal	0.5833
p.R1126Q	DO229268	THCA	ICGC	LSTPRPT	DEG_SCF_FBW7_1	1115:1121	Mutation rewiring degron network	0.1944
p.R1126Q	DO229224	THCA	ICGC	LSTPRPT	DEG_SCF_FBW7_1	1115:1121	Mutation rewiring degron network	0.1944
p.T532K	DO229211	THCA	ICGC	PLTPHGT	DEG_SCF_FBW7_1	529:535	Mutation altering degron motif	0.7306
p.R1126P	DO229213	THCA	ICGC	LSTPRPT	DEG_SCF_FBW7_1	1115:1121	Mutation rewiring degron network	0.1944
p.V526L	DO229234	THCA	ICGC	PLTPHGT	DEG_SCF_FBW7_1	529:535	Mutation rewiring degron network	0.25
p.R1122H	DO223282	UCEC	ICGC	LSTPRPT	DEG_SCF_FBW7_1	1115:1121	Mutation rewiring degron network	0.3056
p.R1298Q	DO41127	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation rewiring degron network	0.1667
p.P1302T	DO43995	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation rewiring degron network	0.0556
p.R1120H	DO229542	UTCA	ICGC	LSTPRPT	DEG_SCF_FBW7_1	1115:1121	Mutation altering degron motif	0.8244
p.T423M	SIDM02021	Esophageal Carcinoma	GDSC	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	409:416	Mutation blocking phosphorylation signal	0.5833
p.A1289V	SIDM00131	Glioma	GDSC	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation altering degron motif	0.6936
p.A1289V	CCF-STTG1	central nervous system	COSMIC	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation altering degron motif	0.6936
p.R1369W	SIDM01023	Acute Myeloid Leukemia	GDSC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation altering degron motif	0.8634
p.R1369W	ACH-000006	Leukemia	CCLE	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation altering degron motif	0.8634
p.R1369W	ACH-001129	Leukemia	CCLE	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation altering degron motif	0.8634
p.R1369W	MONO-MAC-6	haematopoietic and lymphoid tissue	COSMIC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation altering degron motif	0.8634
p.T1117I	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	LSTPRPT	DEG_SCF_FBW7_1	1115:1121	Mutation altering degron motif	0.8189
p.P544Q	SIDM00309	Mesothelioma	GDSC	PLTPHGT	DEG_SCF_FBW7_1	529:535	Mutation rewiring degron network	0.0833
p.R1125W	SIDM00217	Colorectal Carcinoma	GDSC	LSTPRPT	DEG_SCF_FBW7_1	1115:1121	Mutation rewiring degron network	0.2222
p.G1364S	SIDM00431	T-Lymphoblastic Leukemia	GDSC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation rewiring degron network	0.2222
p.G1105E	SIDM01435	Hepatocellular Carcinoma	GDSC	LSTPRPT	DEG_SCF_FBW7_1	1115:1121	Mutation rewiring degron network	0.0556
p.G1105E	ACH-000686	Liver Cancer	CCLE	LSTPRPT	DEG_SCF_FBW7_1	1115:1121	Mutation rewiring degron network	0.0556
p.P541L	ACH-000460	Ovarian Cancer	CCLE	PLTPHGT	DEG_SCF_FBW7_1	529:535	Mutation rewiring degron network	0.1667
p.P541L	ACH-000967	Colon/Colorectal Cancer	CCLE	PLTPHGT	DEG_SCF_FBW7_1	529:535	Mutation rewiring degron network	0.1667
p.R1111H	ACH-000578	Lung Cancer	CCLE	LSTPRPT	DEG_SCF_FBW7_1	1115:1121	Mutation rewiring degron network	0.2222
p.P523S	ACH-000814	Skin Cancer	CCLE	PLTPHGT	DEG_SCF_FBW7_1	529:535	Mutation rewiring degron network	0.1667
p.R1122W	ACH-000999	Colon/Colorectal Cancer	CCLE	LSTPRPT	DEG_SCF_FBW7_1	1115:1121	Mutation rewiring degron network	0.3056
p.N1376Y	ACH-000999	Colon/Colorectal Cancer	CCLE	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation rewiring degron network	0.3056
p.A1382P	ACH-001147	Lymphoma	CCLE	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation rewiring degron network	0.1389
p.L704V	ACH-001853	Bile Duct Cancer	CCLE	MRRRLPQLP	DEG_APCC_DBOX_1	697:705	Mutation altering degron motif	0.5654
p.Q1385R	CTV-1	haematopoietic and lymphoid tissue	COSMIC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation rewiring degron network	0.0556
p.S1371F	SNU-1040	large intestine	COSMIC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation altering degron motif	0.7982
p.S1292F	AN3-CA	endometrium	COSMIC	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation altering degron motif	0.7982
p.R150W	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PEHTPYCE	DEG_SCF_FBW7_2	135:142	Mutation substituting flanking lysine	0.2222
p.V1384L	ESS-1	endometrium	COSMIC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation rewiring degron network	0.0833
p.T1301I	Set2	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation rewiring degron network	0.0833
p.T1301I	LC4-1	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation rewiring degron network	0.0833
p.T1372I	Set2	haematopoietic and lymphoid tissue	COSMIC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation altering degron motif	0.7078
p.T1372I	LC4-1	haematopoietic and lymphoid tissue	COSMIC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation altering degron motif	0.7078
p.R1380Q	KCL-22	haematopoietic and lymphoid tissue	COSMIC	MPSTPAST	DEG_SCF_FBW7_1	1368:1375	Mutation rewiring degron network	0.1944
p.R1298W	769-P	kidney	COSMIC	AGSSS	DEG_SPOP_SBC_1	1288:1292	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEP170B

UniProt ID: Q9Y4F5

Entrez ID: 283638

Protein name: Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEP170B in