DegronMD

Uniprot ID: Q9Y4F5

Source protein: Centrosomal protein of 170 kDa protein B

Source gene: CEP170B

Class: DEG_SCF_FBW7_1

Location: 529:535

E3 ligase: FBXW7

DEGRON score: 0.9939

ASA_SCORE: 101.9429

COIL: 0.9621

CONS_SCORE: 0.3991

DSS_SCORE: 0.7378

HELIX: 0.0134

FCONS_SCORE: 1.0159

RIG_SCORE: 0.5097

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A536T	DO10140	COAD	ICGC	PLTPHGT	DEG_SCF_FBW7_1	0.75
p.E521K	DO35083	PACA	ICGC	PLTPHGT	DEG_SCF_FBW7_1	0.2222
p.P542L	DO229268	THCA	ICGC	PLTPHGT	DEG_SCF_FBW7_1	0.5833
p.T532K	DO229211	THCA	ICGC	PLTPHGT	DEG_SCF_FBW7_1	0.7306
p.V526L	DO229234	THCA	ICGC	PLTPHGT	DEG_SCF_FBW7_1	0.25
p.P544Q	SIDM00309	Mesothelioma	GDSC	PLTPHGT	DEG_SCF_FBW7_1	0.0833
p.P541L	ACH-000460	Ovarian Cancer	CCLE	PLTPHGT	DEG_SCF_FBW7_1	0.1667
p.P541L	ACH-000967	Colon/Colorectal Cancer	CCLE	PLTPHGT	DEG_SCF_FBW7_1	0.1667
p.P523S	ACH-000814	Skin Cancer	CCLE	PLTPHGT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4F5	Centrosomal protein of 170 kDa protein B	DEG_SCF_FBW7_1	529:535	PLTPHGT	FBXW7	0.9939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons