DegronMD

Uniprot ID: Q9Y4F5

Source protein: Centrosomal protein of 170 kDa protein B

Source gene: CEP170B

Class: DEG_SCF_FBW7_2

Location: 135:142

E3 ligase: FBXW7

DEGRON score: 0.5908

ASA_SCORE: 106.325

COIL: 0.9018

CONS_SCORE: 0.2985

DSS_SCORE: 0.6398

HELIX: 0.0673

FCONS_SCORE: 0.7345

RIG_SCORE: 0.6785

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A127V	TCGA-2W-A8YY	CESC	TCGA	PEHTPYCE	DEG_SCF_FBW7_2	0.1111
p.A127V	DO223732	CESC	ICGC	PEHTPYCE	DEG_SCF_FBW7_2	0.1111
p.P146H	TCGA-D3-A3CB	SKCM	TCGA	PEHTPYCE	DEG_SCF_FBW7_2	0.2222
p.P146H	DO47386	SKCM	ICGC	PEHTPYCE	DEG_SCF_FBW7_2	0.2222
p.R139G	DO38069	SKCM	ICGC	PEHTPYCE	DEG_SCF_FBW7_2	0.7568
p.D152G	DO229253	THCA	ICGC	PEHTPYCE	DEG_SCF_FBW7_2	0.0556
p.R150W	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	PEHTPYCE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4F5	Centrosomal protein of 170 kDa protein B	DEG_SCF_FBW7_2	135:142	PEHTPYCE	FBXW7	0.5908	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons