DegronMD

Uniprot ID: Q9Y4F5

Source protein: Centrosomal protein of 170 kDa protein B

Source gene: CEP170B

Class: DEG_SCF_FBW7_1

Location: 1368:1375

E3 ligase: FBXW7

DEGRON score: 0.9212

ASA_SCORE: 82.7125

COIL: 0.904

CONS_SCORE: 0.5492

DSS_SCORE: 0.5865

HELIX: 0.0559

FCONS_SCORE: 1.0917

RIG_SCORE: 0.6123

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1382T	TCGA-UF-A71B	HNSC	TCGA	MPSTPAST	DEG_SCF_FBW7_1	0.1389
p.A1382T	SIDM00602	Gastric Carcinoma	GDSC	MPSTPAST	DEG_SCF_FBW7_1	0.1389
p.A1382T	SIDM01445	Gastric Carcinoma	GDSC	MPSTPAST	DEG_SCF_FBW7_1	0.1389
p.A1382T	ACH-000736	Gastric Cancer	CCLE	MPSTPAST	DEG_SCF_FBW7_1	0.1389
p.A1382T	ACH-000919	Gastric Cancer	CCLE	MPSTPAST	DEG_SCF_FBW7_1	0.1389
p.A1382T	IM-95	stomach	COSMIC	MPSTPAST	DEG_SCF_FBW7_1	0.1389
p.P1370L	DO3317	BRCA	ICGC	MPSTPAST	DEG_SCF_FBW7_1	0.7582
p.A1374S	DO228976	LICA	ICGC	MPSTPAST	DEG_SCF_FBW7_1	0.7588
p.A1374S	DO229015	LICA	ICGC	MPSTPAST	DEG_SCF_FBW7_1	0.7588
p.L1367V	DO27468	LUSC	ICGC	MPSTPAST	DEG_SCF_FBW7_1	0.3056
p.N1385K	DO231284	PACA	ICGC	MPSTPAST	DEG_SCF_FBW7_1	0.0556
p.V1377L	DO37711	SKCM	ICGC	MPSTPAST	DEG_SCF_FBW7_1	0.2778
p.R1380L	DO37794	SKCM	ICGC	MPSTPAST	DEG_SCF_FBW7_1	0.1944
p.R1369W	SIDM01023	Acute Myeloid Leukemia	GDSC	MPSTPAST	DEG_SCF_FBW7_1	0.8634
p.R1369W	ACH-000006	Leukemia	CCLE	MPSTPAST	DEG_SCF_FBW7_1	0.8634
p.R1369W	ACH-001129	Leukemia	CCLE	MPSTPAST	DEG_SCF_FBW7_1	0.8634
p.R1369W	MONO-MAC-6	haematopoietic_and_lymphoid_tissue	COSMIC	MPSTPAST	DEG_SCF_FBW7_1	0.8634
p.G1364S	SIDM00431	T-Lymphoblastic Leukemia	GDSC	MPSTPAST	DEG_SCF_FBW7_1	0.2222
p.N1376Y	ACH-000999	Colon/Colorectal Cancer	CCLE	MPSTPAST	DEG_SCF_FBW7_1	0.3056
p.A1382P	ACH-001147	Lymphoma	CCLE	MPSTPAST	DEG_SCF_FBW7_1	0.1389
p.Q1385R	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	MPSTPAST	DEG_SCF_FBW7_1	0.0556
p.S1371F	SNU-1040	large_intestine	COSMIC	MPSTPAST	DEG_SCF_FBW7_1	0.7982
p.V1384L	ESS-1	endometrium	COSMIC	MPSTPAST	DEG_SCF_FBW7_1	0.0833
p.T1372I	Set2	haematopoietic_and_lymphoid_tissue	COSMIC	MPSTPAST	DEG_SCF_FBW7_1	0.7078
p.T1372I	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	MPSTPAST	DEG_SCF_FBW7_1	0.7078
p.R1380Q	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	MPSTPAST	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MPSTPAST

Degron related mutations and impact score

Drug responses associated with CEP170B mutations

All proteins holding degron of MPSTPAST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4F5	Centrosomal protein of 170 kDa protein B	DEG_SCF_FBW7_1	1368:1375	MPSTPAST	FBXW7	0.9212	More...