DegronMD

Uniprot ID: Q9Y4F5

Source protein: Centrosomal protein of 170 kDa protein B

Source gene: CEP170B

Class: DEG_SCF_FBW7_1

Location: 1115:1121

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 97.2857

COIL: 0.9394

CONS_SCORE: 0.7976

DSS_SCORE: 0.7504

HELIX: 0.0296

FCONS_SCORE: 1.2943

RIG_SCORE: 0.613

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1126W	DO50726	ORCA	ICGC	LSTPRPT	DEG_SCF_FBW7_1	0.1944
p.T1111P	DO219881	SKCA	ICGC	LSTPRPT	DEG_SCF_FBW7_1	0.2222
p.R1126Q	DO229268	THCA	ICGC	LSTPRPT	DEG_SCF_FBW7_1	0.1944
p.R1126Q	DO229224	THCA	ICGC	LSTPRPT	DEG_SCF_FBW7_1	0.1944
p.R1126P	DO229213	THCA	ICGC	LSTPRPT	DEG_SCF_FBW7_1	0.1944
p.R1122H	DO223282	UCEC	ICGC	LSTPRPT	DEG_SCF_FBW7_1	0.3056
p.R1120H	DO229542	UTCA	ICGC	LSTPRPT	DEG_SCF_FBW7_1	0.8244
p.T1117I	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	LSTPRPT	DEG_SCF_FBW7_1	0.8189
p.R1125W	SIDM00217	Colorectal Carcinoma	GDSC	LSTPRPT	DEG_SCF_FBW7_1	0.2222
p.G1105E	SIDM01435	Hepatocellular Carcinoma	GDSC	LSTPRPT	DEG_SCF_FBW7_1	0.0556
p.G1105E	ACH-000686	Liver Cancer	CCLE	LSTPRPT	DEG_SCF_FBW7_1	0.0556
p.R1111H	ACH-000578	Lung Cancer	CCLE	LSTPRPT	DEG_SCF_FBW7_1	0.2222
p.R1122W	ACH-000999	Colon/Colorectal Cancer	CCLE	LSTPRPT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4F5	Centrosomal protein of 170 kDa protein B	DEG_SCF_FBW7_1	1115:1121	LSTPRPT	FBXW7	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons