DegronMD

Uniprot ID: Q9Y4F5

Source protein: Centrosomal protein of 170 kDa protein B

Source gene: CEP170B

Class: DEG_APCC_DBOX_1

Location: 697:705

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9883

ASA_SCORE: 119.9556

COIL: 0.914

CONS_SCORE: 0.6185

DSS_SCORE: 0.75

HELIX: 0.0281

FCONS_SCORE: 1.4101

RIG_SCORE: 0.6645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R697C	DO228119	EOPC	ICGC	MRRRLPQLP	DEG_APCC_DBOX_1	0.8301
p.R699W	DO50898	LICA	ICGC	MRRRLPQLP	DEG_APCC_DBOX_1	0.7523
p.R699W	DO46877	RECA	ICGC	MRRRLPQLP	DEG_APCC_DBOX_1	0.7523
p.P703S	DO222875	MELA	ICGC	MRRRLPQLP	DEG_APCC_DBOX_1	0.6752
p.S693A	DO219876	SKCA	ICGC	MRRRLPQLP	DEG_APCC_DBOX_1	0.2222
p.S693A	DO218910	SKCA	ICGC	MRRRLPQLP	DEG_APCC_DBOX_1	0.2222
p.S693A	DO229084	THCA	ICGC	MRRRLPQLP	DEG_APCC_DBOX_1	0.2222
p.P706S	DO229502	SKCA	ICGC	MRRRLPQLP	DEG_APCC_DBOX_1	0.75
p.R713W	DO38723	STAD	ICGC	MRRRLPQLP	DEG_APCC_DBOX_1	0.1111
p.L704V	ACH-001853	Bile Duct Cancer	CCLE	MRRRLPQLP	DEG_APCC_DBOX_1	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4F5	Centrosomal protein of 170 kDa protein B	DEG_APCC_DBOX_1	697:705	MRRRLPQLP	APC,CDC20,FZR1	0.9883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons