DegronMD

Uniprot ID: Q9Y4F5

Source protein: Centrosomal protein of 170 kDa protein B

Source gene: CEP170B

Class: DEG_SCF_SKP2-CKS1_1

Location: 409:416

E3 ligase: SKP2,CSK1

DEGRON score: 0.963

ASA_SCORE: 109.975

COIL: 0.915

CONS_SCORE: 0.5234

DSS_SCORE: 0.5266

HELIX: 0.0344

FCONS_SCORE: 0.942

RIG_SCORE: 0.7273

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F408L	TCGA-AJ-A5DW	UCEC	TCGA	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	0.3056
p.R415Q	TCGA-BR-7707	STAD	TCGA	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	0.6218
p.R415Q	TCGA-E6-A1LX	UCEC	TCGA	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	0.6218
p.R415Q	TCGA-EO-A22X	UCEC	TCGA	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	0.6218
p.P426L	TCGA-EI-6882	READ	TCGA	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	0.0556
p.R418C	TCGA-PK-A5HB	ACC	TCGA	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	0.2778
p.F404L	TCGA-PL-A8LY	BRCA	TCGA	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	0.1944
p.F404L	DO51217	BRCA	ICGC	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	0.1944
p.R426H	DO232761	PBCA	ICGC	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	0.0556
p.R416Q	DO38487	STAD	ICGC	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	0.7329
p.R416Q	DO41020	UCEC	ICGC	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	0.7329
p.R416Q	DO43907	UCEC	ICGC	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	0.7329
p.T423M	SIDM02021	Esophageal Carcinoma	GDSC	FDEDTPRK	DEG_SCF_SKP2-CKS1_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4F5	Centrosomal protein of 170 kDa protein B	DEG_SCF_SKP2-CKS1_1	409:416	FDEDTPRK	SKP2,CSK1	0.963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons