DegronMD - Q86VE0(MYPOP)

MYPOP

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A293T	TCGA-AZ-6599	COAD	TCGA	LPGTPVDS	DEG_SCF_FBW7_1	298:305	Mutation rewiring degron network	0.1944
p.A293T	DO10606	COAD	ICGC	LPGTPVDS	DEG_SCF_FBW7_1	298:305	Mutation rewiring degron network	0.1944
p.R184Q	TCGA-B5-A11H	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.1667
p.R184Q	DO42825	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.1667
p.R248W	TCGA-G4-6310	COAD	TCGA	PPLAQVAPS	DEG_SIAH_1	231:239	Mutation rewiring degron network	0.0833
p.R248W	DO9442	COAD	ICGC	PPLAQVAPS	DEG_SIAH_1	231:239	Mutation rewiring degron network	0.0833
p.T301P	DO228507	GACA	ICGC	LPGTPVDS	DEG_SCF_FBW7_1	298:305	Mutation altering degron motif	0.7031
p.A293V	DO229240	THCA	ICGC	LPGTPVDS	DEG_SCF_FBW7_1	298:305	Mutation rewiring degron network	0.1944
p.R184W	SIDM00999	Bladder Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.1667
p.R184W	ACH-000973	Bladder Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	174:178	Mutation rewiring degron network	0.1667
p.P314L	ACH-000442	Lung Cancer	CCLE	LPGTPVDS	DEG_SCF_FBW7_1	298:305	Mutation rewiring degron network	0.0833
p.P231S	ACH-000693	Esophageal Cancer	CCLE	PPLAQVAPS	DEG_SIAH_1	231:239	Mutation altering degron motif	0.5641
p.P246R	ACH-000878	Lung Cancer	CCLE	PPLAQVAPS	DEG_SIAH_1	231:239	Mutation rewiring degron network	0.1389
p.P238L	ACH-000995	Leukemia	CCLE	PPLAQVAPS	DEG_SIAH_1	231:239	Mutation altering degron motif	0.7582

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*NOTE: the Kaplan plots were collected from OncoLnc