DegronMD

Uniprot ID: Q86VE0

Source protein: Myb-related transcription factor, partner of profilin

Source gene: MYPOP

Class: DEG_SIAH_1

Location: 231:239

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.7293

ASA_SCORE: 94.5778

COIL: 0.913

CONS_SCORE: 0.3691

DSS_SCORE: 0.756

HELIX: 0.0801

FCONS_SCORE: 0.633

RIG_SCORE: 0.4787

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R248W	TCGA-G4-6310	COAD	TCGA	PPLAQVAPS	DEG_SIAH_1	0.0833
p.R248W	DO9442	COAD	ICGC	PPLAQVAPS	DEG_SIAH_1	0.0833
p.P231S	ACH-000693	Esophageal Cancer	CCLE	PPLAQVAPS	DEG_SIAH_1	0.5641
p.P246R	ACH-000878	Lung Cancer	CCLE	PPLAQVAPS	DEG_SIAH_1	0.1389
p.P238L	ACH-000995	Leukemia	CCLE	PPLAQVAPS	DEG_SIAH_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VE0	Myb-related transcription factor, partner of profilin	DEG_SIAH_1	231:239	PPLAQVAPS	SIAH1,SIAH2,SIAH3	0.7293	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons