DegronMD

Uniprot ID: Q86VE0

Source protein: Myb-related transcription factor, partner of profilin

Source gene: MYPOP

Class: DEG_SCF_FBW7_1

Location: 298:305

E3 ligase: FBXW7

DEGRON score: 0.9364

ASA_SCORE: 83.825

COIL: 0.9598

CONS_SCORE: 0.3969

DSS_SCORE: 0.4911

HELIX: 0.0183

FCONS_SCORE: 0.7298

RIG_SCORE: 0.5831

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A293T	TCGA-AZ-6599	COAD	TCGA	LPGTPVDS	DEG_SCF_FBW7_1	0.1944
p.A293T	DO10606	COAD	ICGC	LPGTPVDS	DEG_SCF_FBW7_1	0.1944
p.T301P	DO228507	GACA	ICGC	LPGTPVDS	DEG_SCF_FBW7_1	0.7031
p.A293V	DO229240	THCA	ICGC	LPGTPVDS	DEG_SCF_FBW7_1	0.1944
p.P314L	ACH-000442	Lung Cancer	CCLE	LPGTPVDS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VE0	Myb-related transcription factor, partner of profilin	DEG_SCF_FBW7_1	298:305	LPGTPVDS	FBXW7	0.9364	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons