DegronMD - O15391(YY2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A127V	TCGA-06-5416	GBM	TCGA	AASTS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.5825
p.A127V	DO10880	GBM	ICGC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.5825
p.E205K	TCGA-55-A492	LUAD	TCGA	PPDY	ITCH	207:210	Mutation rewiring degron network	0.2778
p.E205K	DO23708	LUAD	ICGC	PPDY	ITCH	207:210	Mutation rewiring degron network	0.2778
p.A127S	TCGA-85-A4JB	LUSC	TCGA	AASTS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.7588
p.A127S	DO45517	LUSC	ICGC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.7588
p.T166K	TCGA-99-7458	LUAD	TCGA	AGSSS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.2222
p.T166K	DO25416	LUAD	ICGC	AGSSS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.2222
p.A204T	TCGA-AJ-A3NF	UCEC	TCGA	PPDY	ITCH	207:210	Mutation rewiring degron network	0.25
p.A204T	DO43490	UCEC	ICGC	PPDY	ITCH	207:210	Mutation rewiring degron network	0.25
p.L120M	TCGA-B5-A3FA	UCEC	TCGA	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1389
p.L120M	DO52402	UCEC	ICGC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1389
p.Q203L	TCGA-CK-4948	COAD	TCGA	PPDY	ITCH	207:210	Mutation rewiring degron network	0.2222
p.Q203L	DO10598	COAD	ICGC	PPDY	ITCH	207:210	Mutation rewiring degron network	0.2222
p.S122C	TCGA-CV-A6K2	HNSC	TCGA	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.S122C	DO52079	HNSC	ICGC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.R137H	TCGA-D1-A176	UCEC	TCGA	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1667
p.R137H	DO43947	UCEC	ICGC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1667
p.Y210C	TCGA-D1-A177	UCEC	TCGA	PPDY	ITCH	207:210	Mutation altering degron motif	0.7087
p.Y210C	DO42528	UCEC	ICGC	PPDY	ITCH	207:210	Mutation altering degron motif	0.7087
p.T119I	TCGA-DE-A4MC	THCA	TCGA	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1111
p.T119I	DO39629	THCA	ICGC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1111
p.A121V	TCGA-DU-6407	LGG	TCGA	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1667
p.A121V	DO22295	LGG	ICGC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1667
p.L219H	TCGA-EK-A2R8	CESC	TCGA	PPDY	ITCH	207:210	Mutation rewiring degron network	0.0833
p.L219H	DO51599	CESC	ICGC	PPDY	ITCH	207:210	Mutation rewiring degron network	0.0833
p.S126L	TCGA-XF-AAMR	BLCA	TCGA	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.S126L	DO51935	BLCA	ICGC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.S126L	SIDM00140	Melanoma	GDSC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.S126L	ACH-000968	Skin Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.S126L	COLO-792	skin	COSMIC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.G165S	DO50970	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.25
p.G197E	DO220906	MELA	ICGC	PPDY	ITCH	207:210	Mutation rewiring degron network	0.0556
p.A198T	DO232056	ORCA	ICGC	PPDY	ITCH	207:210	Mutation rewiring degron network	0.0833
p.T130A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.825
p.T130A	ACH-002256	Leukemia	CCLE	AASTS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.825
p.T130A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.825
p.A125V	SIDM00308	Chronic Myelogenous Leukemia	GDSC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2778
p.A125V	ACH-000074	Leukemia	CCLE	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2778
p.A125V	KU812	haematopoietic and lymphoid tissue	COSMIC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2778
p.T166M	SIDM01259	B-Lymphoblastic Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.2222
p.T166M	ACH-001669	Leukemia	CCLE	AGSSS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.2222
p.T166M	ACH-002238	Leukemia	CCLE	AGSSS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.2222
p.T166M	GR-ST	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.2222
p.E212Q	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	PPDY	ITCH	207:210	Mutation rewiring degron network	0.2778
p.E212Q	ACH-001363	Lung Cancer	CCLE	PPDY	ITCH	207:210	Mutation rewiring degron network	0.2778
p.E212Q	NCI-H2135	lung	COSMIC	PPDY	ITCH	207:210	Mutation rewiring degron network	0.2778
p.T132A	SIDM00537	Colorectal Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.T132A	ACH-000982	Colon/Colorectal Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.T132A	ACH-001345	Colon/Colorectal Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.T132A	GP5d	large intestine	COSMIC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.S133L	SIDM00485	Oral Cavity Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2778
p.S133L	ACH-000794	Head and Neck Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2778
p.S133L	BICR22	upper aerodigestive tract	COSMIC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2778
p.K139Q	SIDM01693	B-Lymphoblastic Leukemia	GDSC	AASTS	DEG_SPOP_SBC_1	127:131	Mutation substituting flanking lysine	0.2222
p.K139Q	ACH-000032	Leukemia	CCLE	AASTS	DEG_SPOP_SBC_1	127:131	Mutation substituting flanking lysine	0.2222
p.S152N	ACH-000954	Endometrial/Uterine Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	158:162	Mutation blocking phosphorylation signal	0.6111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

YY2

UniProt ID: O15391

Entrez ID: 404281

Protein name: Transcription factor YY2 (Yin and yang 2) (YY-2) (Zinc finger protein 631)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for YY2 in