DegronMD

Uniprot ID: O15391

Source protein: Transcription factor YY2

Source gene: YY2

Class: DEG_SPOP_SBC_1

Location: 127:131

E3 ligase: SPOP

DEGRON score: 0.8632

ASA_SCORE: 93.38

COIL: 0.942

CONS_SCORE: 0.3604

DSS_SCORE: 0.5612

HELIX: 0.0552

FCONS_SCORE: 0.995

RIG_SCORE: 0.5842

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A127V	TCGA-06-5416	GBM	TCGA	AASTS	DEG_SPOP_SBC_1	0.5825
p.A127V	DO10880	GBM	ICGC	AASTS	DEG_SPOP_SBC_1	0.5825
p.A127S	TCGA-85-A4JB	LUSC	TCGA	AASTS	DEG_SPOP_SBC_1	0.7588
p.A127S	DO45517	LUSC	ICGC	AASTS	DEG_SPOP_SBC_1	0.7588
p.L120M	TCGA-B5-A3FA	UCEC	TCGA	AASTS	DEG_SPOP_SBC_1	0.1389
p.L120M	DO52402	UCEC	ICGC	AASTS	DEG_SPOP_SBC_1	0.1389
p.S122C	TCGA-CV-A6K2	HNSC	TCGA	AASTS	DEG_SPOP_SBC_1	0.1944
p.S122C	DO52079	HNSC	ICGC	AASTS	DEG_SPOP_SBC_1	0.1944
p.R137H	TCGA-D1-A176	UCEC	TCGA	AASTS	DEG_SPOP_SBC_1	0.1667
p.R137H	DO43947	UCEC	ICGC	AASTS	DEG_SPOP_SBC_1	0.1667
p.T119I	TCGA-DE-A4MC	THCA	TCGA	AASTS	DEG_SPOP_SBC_1	0.1111
p.T119I	DO39629	THCA	ICGC	AASTS	DEG_SPOP_SBC_1	0.1111
p.A121V	TCGA-DU-6407	LGG	TCGA	AASTS	DEG_SPOP_SBC_1	0.1667
p.A121V	DO22295	LGG	ICGC	AASTS	DEG_SPOP_SBC_1	0.1667
p.S126L	TCGA-XF-AAMR	BLCA	TCGA	AASTS	DEG_SPOP_SBC_1	0.3056
p.S126L	DO51935	BLCA	ICGC	AASTS	DEG_SPOP_SBC_1	0.3056
p.S126L	SIDM00140	Melanoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.3056
p.S126L	ACH-000968	Skin Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	0.3056
p.S126L	COLO-792	skin	COSMIC	AASTS	DEG_SPOP_SBC_1	0.3056
p.T130A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	AASTS	DEG_SPOP_SBC_1	0.825
p.T130A	ACH-002256	Leukemia	CCLE	AASTS	DEG_SPOP_SBC_1	0.825
p.T130A	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	AASTS	DEG_SPOP_SBC_1	0.825
p.A125V	SIDM00308	Chronic Myelogenous Leukemia	GDSC	AASTS	DEG_SPOP_SBC_1	0.2778
p.A125V	ACH-000074	Leukemia	CCLE	AASTS	DEG_SPOP_SBC_1	0.2778
p.A125V	KU812	haematopoietic_and_lymphoid_tissue	COSMIC	AASTS	DEG_SPOP_SBC_1	0.2778
p.T132A	SIDM00537	Colorectal Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.3056
p.T132A	ACH-000982	Colon/Colorectal Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	0.3056
p.T132A	ACH-001345	Colon/Colorectal Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	0.3056
p.T132A	GP5d	large_intestine	COSMIC	AASTS	DEG_SPOP_SBC_1	0.3056
p.S133L	SIDM00485	Oral Cavity Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2778
p.S133L	ACH-000794	Head and Neck Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	0.2778
p.S133L	BICR22	upper_aerodigestive_tract	COSMIC	AASTS	DEG_SPOP_SBC_1	0.2778
p.K139Q	SIDM01693	B-Lymphoblastic Leukemia	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.K139Q	ACH-000032	Leukemia	CCLE	AASTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15391	Transcription factor YY2	DEG_SPOP_SBC_1	127:131	AASTS	SPOP	0.8632	More...
O15504	Nucleoporin NUP42	DEG_SPOP_SBC_1	274:278	AASTS	SPOP	0.5936	More...
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SPOP_SBC_1	122:126	AASTS	SPOP	0.9939	More...
O75113	NEDD4-binding protein 1	DEG_SPOP_SBC_1	804:808	AASTS	SPOP	0.9913	More...
O95259	Potassium voltage-gated channel subfamily H member 1	DEG_SPOP_SBC_1	802:806	AASTS	SPOP	0.8742	More...
O95721	Synaptosomal-associated protein 29	DEG_SPOP_SBC_1	57:61	AASTS	SPOP	0.8495	More...
P11473	Vitamin D3 receptor	DEG_SPOP_SBC_1	5:9	AASTS	SPOP	0.7318	More...
P18827	Syndecan-1	DEG_SPOP_SBC_1	87:91	AASTS	SPOP	0.9596	More...
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	21:25	AASTS	SPOP	0.9238	More...
Q13049	E3 ubiquitin-protein ligase TRIM32	DEG_SPOP_SBC_1	315:319	AASTS	SPOP	0.925	More...
Q14669	E3 ubiquitin-protein ligase TRIP12	DEG_SPOP_SBC_1	199:203	AASTS	SPOP	0.9879	More...
Q2KHT3	Protein CLEC16A	DEG_SPOP_SBC_1	450:454	AASTS	SPOP	0.6135	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	1155:1159	AASTS	SPOP	0.7759	More...
Q8IYG6	Leucine-rich repeat-containing protein 56	DEG_SPOP_SBC_1	363:367	AASTS	SPOP	0.8439	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2095:2099	AASTS	SPOP	0.5839	More...
Q9BWF3	RNA-binding protein 4	DEG_SPOP_SBC_1	298:302	AASTS	SPOP	0.9032	More...
Q9HC35	Echinoderm microtubule-associated protein-like 4	DEG_SPOP_SBC_1	14:18	AASTS	SPOP	0.9981	More...
Q9P2R6	Arginine-glutamic acid dipeptide repeats protein	DEG_SPOP_SBC_1	616:620	AASTS	SPOP	0.997	More...
Q9UJX2	Cell division cycle protein 23 homolog	DEG_SPOP_SBC_1	2:6	AASTS	SPOP	0.5243	More...
O95081	Arf-GAP domain and FG repeat-containing protein 2	DEG_SPOP_SBC_1	189:193	AASTS	SPOP	0.9166	More...
Q8TC56	Golgi associated RAB2 interactor protein 3	DEG_SPOP_SBC_1	348:352	AASTS	SPOP	0.9521	More...
A6NL46	Putative UPF0607 protein ENSP00000332738	DEG_SPOP_SBC_1	108:112	AASTS	SPOP	0.9403	More...
A8MUA0	Putative UPF0607 protein ENSP00000381514	DEG_SPOP_SBC_1	109:113	AASTS	SPOP	0.7629	More...
A8MV72	Putative UPF0607 protein ENSP00000382826	DEG_SPOP_SBC_1	79:83	AASTS	SPOP	0.8388	More...
A8MX80	Putative UPF0607 protein ENSP00000383144	DEG_SPOP_SBC_1	109:113	AASTS	SPOP	0.6735	More...
Q5PR19	Putative UPF0607 protein LOC392364	DEG_SPOP_SBC_1	146:150	AASTS	SPOP	0.6539	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	414:418	AASTS	SPOP	0.97	More...
Q8N9G6	Putative UPF0607 protein FLJ37424	DEG_SPOP_SBC_1	109:113	AASTS	SPOP	0.878	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AASTS

Degron related mutations and impact score

Drug responses associated with YY2 mutations

All proteins holding degron of AASTS