DegronMD - Q2KHT3(CLEC16A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S454F	TCGA-55-6979	LUAD	TCGA	AASTS	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.7982
p.S447L	TCGA-55-8092	LUAD	TCGA	AASTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.25
p.Q932H	TCGA-98-8021	LUSC	TCGA	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.1111
p.Q932H	DO27468	LUSC	ICGC	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.1111
p.D918N	TCGA-AJ-A3EK	UCEC	TCGA	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation altering degron motif	0.6932
p.D918N	DO41584	UCEC	ICGC	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation altering degron motif	0.6932
p.D918N	SIDM01113	Other Sarcomas	GDSC	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation altering degron motif	0.6932
p.D918N	ACH-000939	Sarcoma	CCLE	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation altering degron motif	0.6932
p.D918N	SK-UT-1	soft tissue	COSMIC	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation altering degron motif	0.6932
p.S924L	TCGA-BF-AAP2	SKCM	TCGA	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation altering degron motif	0.6556
p.S924L	TCGA-BF-AAP6	SKCM	TCGA	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation altering degron motif	0.6556
p.S924L	TCGA-D3-A8GM	SKCM	TCGA	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation altering degron motif	0.6556
p.S924L	DO50288	SKCM	ICGC	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation altering degron motif	0.6556
p.S924L	DO219470	SKCM	ICGC	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation altering degron motif	0.6556
p.S924L	DO219466	SKCM	ICGC	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation altering degron motif	0.6556
p.A450V	TCGA-BG-A18B	UCEC	TCGA	AASTS	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.5825
p.S444N	TCGA-CN-4725	HNSC	TCGA	AASTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.1667
p.S444R	TCGA-FR-A729	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.1667
p.A450T	DO8778	COAD	ICGC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.7139
p.A450T	DO46657	PAAD	ICGC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.7139
p.A450T	SIDM01240	Melanoma	GDSC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.7139
p.A450T	ACH-001002	Skin Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.7139
p.A450T	451Lu	skin	COSMIC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.7139
p.A451T	DO23468	LINC	ICGC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.6028
p.A451T	DO50127	STAD	ICGC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.6028
p.A451T	DO51773	STAD	ICGC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.6028
p.A451T	DO41871	UCEC	ICGC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.6028
p.A451T	SIDM00969	Ovarian Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.6028
p.A451T	SK-UT-1	soft tissue	COSMIC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.6028
p.A451T	DOV13	ovary	COSMIC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.6028
p.A450S	DO45509	LUSC	ICGC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.7588
p.G910S	DO27891	ORCA	ICGC	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.1111
p.G910S	DO35597	PBCA	ICGC	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.1111
p.T914P	DO229453	SKCA	ICGC	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.2222
p.T914P	DO227681	SKCA	ICGC	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.2222
p.L464P	DO229232	THCA	ICGC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.0556
p.R443H	SIDM01037	Breast Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.1389
p.R443H	JIMT-1	breast	COSMIC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.1389
p.P934T	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.0556
p.P934T	ACH-000562	Lung Cancer	CCLE	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.0556
p.P934T	HCC-78	lung	COSMIC	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.0556
p.Q456H	SIDM00845	Burkitt's Lymphoma	GDSC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.2778
p.Q456H	ACH-000786	Lymphoma	CCLE	AASTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.2778
p.Q456H	Daudi	haematopoietic and lymphoid tissue	COSMIC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.2778
p.A931S	SIDM00789	Colorectal Carcinoma	GDSC	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.1389
p.A931S	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.1389
p.A931S	ACH-001061	Colon/Colorectal Cancer	CCLE	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.1389
p.G920E	SIDM01154	T-Lymphoblastic Leukemia	GDSC	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation altering degron motif	0.7199
p.G920E	ACH-000953	Leukemia	CCLE	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation altering degron motif	0.7199
p.G920E	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation altering degron motif	0.7199
p.G912R	SIDM01608	Endometrial Carcinoma	GDSC	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.1667
p.A451S	ACH-000872	Lung Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.6477
p.G912W	ESS-1	endometrium	COSMIC	DSGGTSS	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.1667
p.S460N	RH-18	soft tissue	COSMIC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.1667
p.W459R	EW-7	bone	COSMIC	AASTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLEC16A

UniProt ID: Q2KHT3

Entrez ID: 23274

Protein name: Protein CLEC16A (C-type lectin domain family 16 member A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLEC16A in