DegronMD

Uniprot ID: Q2KHT3

Source protein: Protein CLEC16A

Source gene: CLEC16A

Class: DEG_SCF_TRCP1_1

Location: 918:924

E3 ligase: BTRC

DEGRON score: 0.8249

ASA_SCORE: 74.7857

COIL: 0.9077

CONS_SCORE: 0.2942

DSS_SCORE: 0.7265

HELIX: 0.0267

FCONS_SCORE: 0.9733

RIG_SCORE: 0.4357

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q932H	TCGA-98-8021	LUSC	TCGA	DSGGTSS	DEG_SCF_TRCP1_1	0.1111
p.Q932H	DO27468	LUSC	ICGC	DSGGTSS	DEG_SCF_TRCP1_1	0.1111
p.D918N	TCGA-AJ-A3EK	UCEC	TCGA	DSGGTSS	DEG_SCF_TRCP1_1	0.6932
p.D918N	DO41584	UCEC	ICGC	DSGGTSS	DEG_SCF_TRCP1_1	0.6932
p.D918N	SIDM01113	Other Sarcomas	GDSC	DSGGTSS	DEG_SCF_TRCP1_1	0.6932
p.D918N	ACH-000939	Sarcoma	CCLE	DSGGTSS	DEG_SCF_TRCP1_1	0.6932
p.D918N	SK-UT-1	soft_tissue	COSMIC	DSGGTSS	DEG_SCF_TRCP1_1	0.6932
p.S924L	TCGA-BF-AAP2	SKCM	TCGA	DSGGTSS	DEG_SCF_TRCP1_1	0.6556
p.S924L	TCGA-BF-AAP6	SKCM	TCGA	DSGGTSS	DEG_SCF_TRCP1_1	0.6556
p.S924L	TCGA-D3-A8GM	SKCM	TCGA	DSGGTSS	DEG_SCF_TRCP1_1	0.6556
p.S924L	DO50288	SKCM	ICGC	DSGGTSS	DEG_SCF_TRCP1_1	0.6556
p.S924L	DO219470	SKCM	ICGC	DSGGTSS	DEG_SCF_TRCP1_1	0.6556
p.S924L	DO219466	SKCM	ICGC	DSGGTSS	DEG_SCF_TRCP1_1	0.6556
p.G910S	DO27891	ORCA	ICGC	DSGGTSS	DEG_SCF_TRCP1_1	0.1111
p.G910S	DO35597	PBCA	ICGC	DSGGTSS	DEG_SCF_TRCP1_1	0.1111
p.T914P	DO229453	SKCA	ICGC	DSGGTSS	DEG_SCF_TRCP1_1	0.2222
p.T914P	DO227681	SKCA	ICGC	DSGGTSS	DEG_SCF_TRCP1_1	0.2222
p.P934T	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	DSGGTSS	DEG_SCF_TRCP1_1	0.0556
p.P934T	ACH-000562	Lung Cancer	CCLE	DSGGTSS	DEG_SCF_TRCP1_1	0.0556
p.P934T	HCC-78	lung	COSMIC	DSGGTSS	DEG_SCF_TRCP1_1	0.0556
p.A931S	SIDM00789	Colorectal Carcinoma	GDSC	DSGGTSS	DEG_SCF_TRCP1_1	0.1389
p.A931S	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGGTSS	DEG_SCF_TRCP1_1	0.1389
p.A931S	ACH-001061	Colon/Colorectal Cancer	CCLE	DSGGTSS	DEG_SCF_TRCP1_1	0.1389
p.G920E	SIDM01154	T-Lymphoblastic Leukemia	GDSC	DSGGTSS	DEG_SCF_TRCP1_1	0.7199
p.G920E	ACH-000953	Leukemia	CCLE	DSGGTSS	DEG_SCF_TRCP1_1	0.7199
p.G920E	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGGTSS	DEG_SCF_TRCP1_1	0.7199
p.G912R	SIDM01608	Endometrial Carcinoma	GDSC	DSGGTSS	DEG_SCF_TRCP1_1	0.1667
p.G912W	ESS-1	endometrium	COSMIC	DSGGTSS	DEG_SCF_TRCP1_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGGTSS

Degron related mutations and impact score

Drug responses associated with CLEC16A mutations

All proteins holding degron of DSGGTSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2KHT3	Protein CLEC16A	DEG_SCF_TRCP1_1	918:924	DSGGTSS	BTRC	0.8249	More...