DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 2095:2099

E3 ligase: SPOP

DEGRON score: 0.5839

ASA_SCORE: 84.06

COIL: 0.9026

CONS_SCORE: 0

DSS_SCORE: 0.6197

HELIX: 0.0354

FCONS_SCORE: 0

RIG_SCORE: 0.6733

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2088N	TCGA-33-AASI	LUSC	TCGA	AASTS	DEG_SPOP_SBC_1	0.1389
p.T2088N	DO219129	LUSC	ICGC	AASTS	DEG_SPOP_SBC_1	0.1389
p.A2100S	TCGA-95-7567	LUAD	TCGA	AASTS	DEG_SPOP_SBC_1	0.3056
p.A2100S	DO25564	LUAD	ICGC	AASTS	DEG_SPOP_SBC_1	0.3056
p.E2107G	TCGA-B5-A1MR	UCEC	TCGA	AASTS	DEG_SPOP_SBC_1	0.1111
p.E2107G	DO41758	UCEC	ICGC	AASTS	DEG_SPOP_SBC_1	0.1111
p.S2099C	TCGA-BR-7704	STAD	TCGA	AASTS	DEG_SPOP_SBC_1	0.7541
p.S2099C	DO38360	STAD	ICGC	AASTS	DEG_SPOP_SBC_1	0.7541
p.S2094L	TCGA-EE-A29P	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	0.3056
p.S2094L	DO37916	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	0.3056
p.R2104K	TCGA-EE-A3J8	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	0.1944
p.R2104K	TCGA-FR-A726	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	0.1944
p.R2104K	TCGA-FW-A3R5	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	0.1944
p.R2104K	DO47276	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	0.1944
p.R2104K	DO37406	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	0.1944
p.R2104K	DO48665	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	0.1944
p.P2091S	TCGA-EE-A3JD	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	0.2222
p.P2091S	TCGA-FR-A8YC	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	0.2222
p.P2091S	DO229459	SKCA	ICGC	AASTS	DEG_SPOP_SBC_1	0.2222
p.P2091S	DO50301	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	0.2222
p.P2091S	DO50299	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	0.2222
p.P2091S	ACH-002005	Skin Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	0.2222
p.E2089K	TCGA-ER-A19O	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	0.1667
p.E2089K	TCGA-Z2-A8RT	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	0.1667
p.E2089K	DO38063	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	0.1667
p.E2089K	DO51301	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	0.1667
p.P2106L	TCGA-FW-A3R5	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	0.1389
p.P2106L	DO37406	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	0.1389
p.F2090C	TCGA-IB-7651	PAAD	TCGA	AASTS	DEG_SPOP_SBC_1	0.1944
p.F2090C	DO46657	PAAD	ICGC	AASTS	DEG_SPOP_SBC_1	0.1944
p.S2099Y	TCGA-JY-A6FG	ESCA	TCGA	AASTS	DEG_SPOP_SBC_1	0.712
p.A2100D	DO52124	PAEN	ICGC	AASTS	DEG_SPOP_SBC_1	0.3056
p.F2090Y	DO229502	SKCA	ICGC	AASTS	DEG_SPOP_SBC_1	0.1944
p.E2089D	SIDM01397	Melanoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.1667
p.E2089D	ACH-000765	Skin Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	0.1667
p.P2106S	SIDM01768	Melanoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.1389
p.P2106S	ACH-000899	Skin Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15391	Transcription factor YY2	DEG_SPOP_SBC_1	127:131	AASTS	SPOP	0.8632	More...
O15504	Nucleoporin NUP42	DEG_SPOP_SBC_1	274:278	AASTS	SPOP	0.5936	More...
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SPOP_SBC_1	122:126	AASTS	SPOP	0.9939	More...
O75113	NEDD4-binding protein 1	DEG_SPOP_SBC_1	804:808	AASTS	SPOP	0.9913	More...
O95259	Potassium voltage-gated channel subfamily H member 1	DEG_SPOP_SBC_1	802:806	AASTS	SPOP	0.8742	More...
O95721	Synaptosomal-associated protein 29	DEG_SPOP_SBC_1	57:61	AASTS	SPOP	0.8495	More...
P11473	Vitamin D3 receptor	DEG_SPOP_SBC_1	5:9	AASTS	SPOP	0.7318	More...
P18827	Syndecan-1	DEG_SPOP_SBC_1	87:91	AASTS	SPOP	0.9596	More...
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	21:25	AASTS	SPOP	0.9238	More...
Q13049	E3 ubiquitin-protein ligase TRIM32	DEG_SPOP_SBC_1	315:319	AASTS	SPOP	0.925	More...
Q14669	E3 ubiquitin-protein ligase TRIP12	DEG_SPOP_SBC_1	199:203	AASTS	SPOP	0.9879	More...
Q2KHT3	Protein CLEC16A	DEG_SPOP_SBC_1	450:454	AASTS	SPOP	0.6135	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	1155:1159	AASTS	SPOP	0.7759	More...
Q8IYG6	Leucine-rich repeat-containing protein 56	DEG_SPOP_SBC_1	363:367	AASTS	SPOP	0.8439	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2095:2099	AASTS	SPOP	0.5839	More...
Q9BWF3	RNA-binding protein 4	DEG_SPOP_SBC_1	298:302	AASTS	SPOP	0.9032	More...
Q9HC35	Echinoderm microtubule-associated protein-like 4	DEG_SPOP_SBC_1	14:18	AASTS	SPOP	0.9981	More...
Q9P2R6	Arginine-glutamic acid dipeptide repeats protein	DEG_SPOP_SBC_1	616:620	AASTS	SPOP	0.997	More...
Q9UJX2	Cell division cycle protein 23 homolog	DEG_SPOP_SBC_1	2:6	AASTS	SPOP	0.5243	More...
O95081	Arf-GAP domain and FG repeat-containing protein 2	DEG_SPOP_SBC_1	189:193	AASTS	SPOP	0.9166	More...
Q8TC56	Golgi associated RAB2 interactor protein 3	DEG_SPOP_SBC_1	348:352	AASTS	SPOP	0.9521	More...
A6NL46	Putative UPF0607 protein ENSP00000332738	DEG_SPOP_SBC_1	108:112	AASTS	SPOP	0.9403	More...
A8MUA0	Putative UPF0607 protein ENSP00000381514	DEG_SPOP_SBC_1	109:113	AASTS	SPOP	0.7629	More...
A8MV72	Putative UPF0607 protein ENSP00000382826	DEG_SPOP_SBC_1	79:83	AASTS	SPOP	0.8388	More...
A8MX80	Putative UPF0607 protein ENSP00000383144	DEG_SPOP_SBC_1	109:113	AASTS	SPOP	0.6735	More...
Q5PR19	Putative UPF0607 protein LOC392364	DEG_SPOP_SBC_1	146:150	AASTS	SPOP	0.6539	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	414:418	AASTS	SPOP	0.97	More...
Q8N9G6	Putative UPF0607 protein FLJ37424	DEG_SPOP_SBC_1	109:113	AASTS	SPOP	0.878	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AASTS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of AASTS