DegronMD - Q9BWF3(RBM4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R349Q	DO8119	COAD	ICGC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.3056
p.G305R	DO8447	COAD	ICGC	AASTS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.25
p.E330A	DO233179	GACA	ICGC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.0556
p.R341Q	DO233766	GACA	ICGC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation altering degron motif	0.7329
p.R341Q	SIDM01090	Colorectal Carcinoma	GDSC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation altering degron motif	0.7329
p.R341Q	RKO	large intestine	COSMIC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation altering degron motif	0.7329
p.A340V	DO13522	GBM	ICGC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation altering degron motif	0.5825
p.A340V	DO23448	LINC	ICGC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation altering degron motif	0.5825
p.L333F	DO228948	LICA	ICGC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.1389
p.A336S	DO229026	LICA	ICGC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.2222
p.R341L	DO229037	LICA	ICGC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation altering degron motif	0.8428
p.T301S	DO45346	LUAD	ICGC	AASTS	DEG_SPOP_SBC_1	298:302	Mutation altering degron motif	0.7116
p.R358L	DO37420	SKCM	ICGC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.0556
p.A293T	DO42280	UCEC	ICGC	AASTS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.1944
p.A293T	DO41379	UCEC	ICGC	AASTS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.1944
p.A292V	DO41752	UCEC	ICGC	AASTS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.1667
p.S300F	SIDM00545	Melanoma	GDSC	AASTS	DEG_SPOP_SBC_1	298:302	Mutation altering degron motif	0.7982
p.E330D	SIDM00845	Burkitt's Lymphoma	GDSC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.0556
p.E330D	Daudi	haematopoietic and lymphoid tissue	COSMIC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.0556
p.A338T	SIDM01245	T-Lymphoblastic Leukemia	GDSC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.2778
p.A338T	SIDM00991	T-Lymphoblastic Leukemia	GDSC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.2778
p.A338T	BE-13	haematopoietic and lymphoid tissue	COSMIC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.2778
p.E330K	SIDM00754	Non-Small Cell Lung Carcinoma	GDSC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.0556
p.E330K	NCI-H1781	lung	COSMIC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.0556
p.E332K	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.1111
p.E332K	ACH-000694	Esophageal Cancer	CCLE	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.1111
p.E332K	TE-9	oesophagus	COSMIC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.1111
p.A338V	SIDM01617	Endometrial Carcinoma	GDSC	ARNSLYDMA	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.2778
p.R306W	SIDM00500	Colorectal Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.2222
p.Y303H	Daudi	haematopoietic and lymphoid tissue	COSMIC	AASTS	DEG_SPOP_SBC_1	298:302	Mutation blocking phosphorylation signal	0.75

Kaplan plot for RBM4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM4

UniProt ID: Q9BWF3

Entrez ID: 5936

Protein name: RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBM4 in