DegronMD

Uniprot ID: Q9BWF3

Source protein: RNA-binding protein 4

Source gene: RBM4

Class: DEG_APCC_DBOX_1

Location: 340:348

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5544

ASA_SCORE: 89.3889

COIL: 0.526

CONS_SCORE: 0.3756

DSS_SCORE: 0.3214

HELIX: 0.4604

FCONS_SCORE: 0.8659

RIG_SCORE: 0.7879

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R349Q	DO8119	COAD	ICGC	ARNSLYDMA	DEG_APCC_DBOX_1	0.3056
p.E330A	DO233179	GACA	ICGC	ARNSLYDMA	DEG_APCC_DBOX_1	0.0556
p.R341Q	DO233766	GACA	ICGC	ARNSLYDMA	DEG_APCC_DBOX_1	0.7329
p.R341Q	SIDM01090	Colorectal Carcinoma	GDSC	ARNSLYDMA	DEG_APCC_DBOX_1	0.7329
p.R341Q	RKO	large_intestine	COSMIC	ARNSLYDMA	DEG_APCC_DBOX_1	0.7329
p.A340V	DO13522	GBM	ICGC	ARNSLYDMA	DEG_APCC_DBOX_1	0.5825
p.A340V	DO23448	LINC	ICGC	ARNSLYDMA	DEG_APCC_DBOX_1	0.5825
p.L333F	DO228948	LICA	ICGC	ARNSLYDMA	DEG_APCC_DBOX_1	0.1389
p.A336S	DO229026	LICA	ICGC	ARNSLYDMA	DEG_APCC_DBOX_1	0.2222
p.R341L	DO229037	LICA	ICGC	ARNSLYDMA	DEG_APCC_DBOX_1	0.8428
p.R358L	DO37420	SKCM	ICGC	ARNSLYDMA	DEG_APCC_DBOX_1	0.0556
p.E330D	SIDM00845	Burkitt's Lymphoma	GDSC	ARNSLYDMA	DEG_APCC_DBOX_1	0.0556
p.E330D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ARNSLYDMA	DEG_APCC_DBOX_1	0.0556
p.A338T	SIDM01245	T-Lymphoblastic Leukemia	GDSC	ARNSLYDMA	DEG_APCC_DBOX_1	0.2778
p.A338T	SIDM00991	T-Lymphoblastic Leukemia	GDSC	ARNSLYDMA	DEG_APCC_DBOX_1	0.2778
p.A338T	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	ARNSLYDMA	DEG_APCC_DBOX_1	0.2778
p.E330K	SIDM00754	Non-Small Cell Lung Carcinoma	GDSC	ARNSLYDMA	DEG_APCC_DBOX_1	0.0556
p.E330K	NCI-H1781	lung	COSMIC	ARNSLYDMA	DEG_APCC_DBOX_1	0.0556
p.E332K	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	ARNSLYDMA	DEG_APCC_DBOX_1	0.1111
p.E332K	ACH-000694	Esophageal Cancer	CCLE	ARNSLYDMA	DEG_APCC_DBOX_1	0.1111
p.E332K	TE-9	oesophagus	COSMIC	ARNSLYDMA	DEG_APCC_DBOX_1	0.1111
p.A338V	SIDM01617	Endometrial Carcinoma	GDSC	ARNSLYDMA	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BWF3	RNA-binding protein 4	DEG_APCC_DBOX_1	340:348	ARNSLYDMA	APC,CDC20,FZR1	0.5544	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons