DegronMD - Q8TC56(GARIN3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T244M	TCGA-19-5956	GBM	TCGA	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1667
p.T244M	DO13863	GBM	ICGC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1667
p.T244M	DO51476	PACA	ICGC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1667
p.A361V	TCGA-2L-AAQJ	PAAD	TCGA	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0833
p.A361V	TCGA-32-1979	GBM	TCGA	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0833
p.A361V	DO11842	GBM	ICGC	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0833
p.A361V	DO218949	PAAD	ICGC	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0833
p.P220A	TCGA-55-1595	LUAD	TCGA	AATSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.1944
p.P220A	DO23558	LUAD	ICGC	AATSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.1944
p.G216R	TCGA-78-8660	LUAD	TCGA	AATSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.0833
p.G216R	DO45321	LUAD	ICGC	AATSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.0833
p.H239Q	TCGA-91-6836	LUAD	TCGA	AATSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.0556
p.H239Q	DO23854	LUAD	ICGC	AATSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.0556
p.S253I	TCGA-97-8172	LUAD	TCGA	PSTST	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.7341
p.S253I	DO26384	LUAD	ICGC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.7341
p.G243R	TCGA-B5-A0JY	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.G243R	DO43041	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.S228T	TCGA-BB-A5HY	HNSC	TCGA	AATSS	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.6005
p.S228T	DO218979	HNSC	ICGC	AATSS	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.6005
p.G236R	TCGA-BF-A1PV	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.1389
p.G236R	DO47309	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.1389
p.E354G	TCGA-BH-A0WA	BRCA	TCGA	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.2778
p.E354G	DO2897	BRCA	ICGC	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.2778
p.G233A	TCGA-BI-A0VS	CESC	TCGA	AATSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.2222
p.G233A	DO6263	CESC	ICGC	AATSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.2222
p.S342R	TCGA-BR-4371	STAD	TCGA	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1667
p.S342R	DO38348	STAD	ICGC	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1667
p.E339G	TCGA-D3-A1Q4	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0833
p.E339G	DO47631	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0833
p.A344V	TCGA-D3-A5GS	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.2222
p.A344V	DO47706	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.2222
p.A245T	TCGA-D9-A1JW	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1944
p.A245T	DO37786	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1944
p.A245T	SIDM01059	Melanoma	GDSC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1944
p.A245T	ACH-000915	Skin Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1944
p.A245T	IPC-298	skin	COSMIC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1944
p.A225V	TCGA-DF-A2KU	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.5825
p.A225V	DO223286	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.5825
p.A263T	TCGA-DI-A1BU	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.0833
p.A263T	DO42023	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.0833
p.A248T	TCGA-EE-A29C	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.2778
p.A248T	TCGA-IH-A3EA	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.2778
p.A248T	DO37667	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.2778
p.A248T	DO38028	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.2778
p.T215N	TCGA-EO-A22U	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.0556
p.T215N	DO43755	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.0556
p.P250S	TCGA-ER-A1A1	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.6752
p.P250S	TCGA-QC-A7B5	SARC	TCGA	PSTST	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.6752
p.P250S	DO220239	SARC	ICGC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.6752
p.P250S	DO37413	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.6752
p.G233E	TCGA-FS-A4F5	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.2222
p.G233E	DO37881	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.2222
p.R264K	TCGA-FW-A3R5	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.0556
p.R264K	DO222647	MELA	ICGC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.0556
p.R264K	DO37406	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.0556
p.H239L	TCGA-NC-A5HP	LUSC	TCGA	AATSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.0556
p.H239L	DO219199	LUSC	ICGC	AATSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.0556
p.P250L	TCGA-QC-A7B5	SARC	TCGA	PSTST	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.7582
p.P250L	DO220239	SARC	ICGC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.7582
p.A247V	TCGA-QQ-A8VF	SARC	TCGA	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.25
p.A247V	DO220258	SARC	ICGC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.25
p.G243E	TCGA-YG-AA3N	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.G243E	DO51298	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.P220T	TCGA-ZH-A8Y6	CHOL	TCGA	AATSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.1944
p.S342C	DO233284	GACA	ICGC	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1667
p.S350N	DO228284	LICA	ICGC	AASTS	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.7069
p.T252K	DO228948	LICA	ICGC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.7306
p.A225E	DO229032	LICA	ICGC	AATSS	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7701
p.T358I	DO231655	LINC	ICGC	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1667
p.K219Q	DO222405	MELA	ICGC	AATSS	DEG_SPOP_SBC_1	225:229	Mutation substituting flanking lysine	0.2778
p.G260E	DO222647	MELA	ICGC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1667
p.T254S	DO35245	PACA	ICGC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.6005
p.E235V	DO229216	THCA	ICGC	AATSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.1667
p.A258V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.2222
p.A258V	ACH-000981	Leukemia	CCLE	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.2222
p.A258V	DND-41	haematopoietic and lymphoid tissue	COSMIC	PSTST	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.2222
p.S338L	SIDM00064	Hepatocellular Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0556
p.S338L	ACH-000393	Liver Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0556
p.S338L	ACH-001089	Liver Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0556
p.S338L	HLE	liver	COSMIC	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0556
p.S229F	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7982
p.S229F	ACH-000305	Esophageal Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7982
p.S229F	EC-GI-10	oesophagus	COSMIC	AATSS	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7982
p.T227S	SIDM00498	Colorectal Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.6005
p.T227S	ACH-000970	Colon/Colorectal Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.6005
p.T227S	SNU-C5	large intestine	COSMIC	AATSS	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.6005
p.T358P	ACH-001453	Prostate Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GARIN3

UniProt ID: Q8TC56

Entrez ID: 153745

Protein name: Golgi associated RAB2 interactor protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GARIN3 in