DegronMD

Uniprot ID: Q8TC56

Source protein: Golgi associated RAB2 interactor protein 3

Source gene: GARIN3

Class: DEG_SPOP_SBC_1

Location: 225:229

E3 ligase: SPOP

DEGRON score: 0.8742

ASA_SCORE: 66.1

COIL: 0.773

CONS_SCORE: 0.6774

DSS_SCORE: 0.3905

HELIX: 0.1844

FCONS_SCORE: 1.3288

RIG_SCORE: 0.715

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P220A	TCGA-55-1595	LUAD	TCGA	AATSS	DEG_SPOP_SBC_1	0.1944
p.P220A	DO23558	LUAD	ICGC	AATSS	DEG_SPOP_SBC_1	0.1944
p.G216R	TCGA-78-8660	LUAD	TCGA	AATSS	DEG_SPOP_SBC_1	0.0833
p.G216R	DO45321	LUAD	ICGC	AATSS	DEG_SPOP_SBC_1	0.0833
p.H239Q	TCGA-91-6836	LUAD	TCGA	AATSS	DEG_SPOP_SBC_1	0.0556
p.H239Q	DO23854	LUAD	ICGC	AATSS	DEG_SPOP_SBC_1	0.0556
p.S228T	TCGA-BB-A5HY	HNSC	TCGA	AATSS	DEG_SPOP_SBC_1	0.6005
p.S228T	DO218979	HNSC	ICGC	AATSS	DEG_SPOP_SBC_1	0.6005
p.G236R	TCGA-BF-A1PV	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	0.1389
p.G236R	DO47309	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	0.1389
p.G233A	TCGA-BI-A0VS	CESC	TCGA	AATSS	DEG_SPOP_SBC_1	0.2222
p.G233A	DO6263	CESC	ICGC	AATSS	DEG_SPOP_SBC_1	0.2222
p.A225V	TCGA-DF-A2KU	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	0.5825
p.A225V	DO223286	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	0.5825
p.T215N	TCGA-EO-A22U	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	0.0556
p.T215N	DO43755	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	0.0556
p.G233E	TCGA-FS-A4F5	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	0.2222
p.G233E	DO37881	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	0.2222
p.H239L	TCGA-NC-A5HP	LUSC	TCGA	AATSS	DEG_SPOP_SBC_1	0.0556
p.H239L	DO219199	LUSC	ICGC	AATSS	DEG_SPOP_SBC_1	0.0556
p.P220T	TCGA-ZH-A8Y6	CHOL	TCGA	AATSS	DEG_SPOP_SBC_1	0.1944
p.A225E	DO229032	LICA	ICGC	AATSS	DEG_SPOP_SBC_1	0.7701
p.K219Q	DO222405	MELA	ICGC	AATSS	DEG_SPOP_SBC_1	0.2778
p.E235V	DO229216	THCA	ICGC	AATSS	DEG_SPOP_SBC_1	0.1667
p.S229F	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	0.7982
p.S229F	ACH-000305	Esophageal Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	0.7982
p.S229F	EC-GI-10	oesophagus	COSMIC	AATSS	DEG_SPOP_SBC_1	0.7982
p.T227S	SIDM00498	Colorectal Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	0.6005
p.T227S	ACH-000970	Colon/Colorectal Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	0.6005
p.T227S	SNU-C5	large_intestine	COSMIC	AATSS	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43166	Signal-induced proliferation-associated 1-like protein 1	DEG_SPOP_SBC_1	1345:1349	AATSS	SPOP	0.9959	More...
P30414	NK-tumor recognition protein	DEG_SPOP_SBC_1	1240:1244	AATSS	SPOP	0.574	More...
P51575	P2X purinoceptor 1	DEG_SPOP_SBC_1	384:388	AATSS	SPOP	0.9498	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3473:3477	AATSS	SPOP	0.9561	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3906:3910	AATSS	SPOP	0.9778	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4212:4216	AATSS	SPOP	0.9754	More...
Q02447	Transcription factor Sp3	DEG_SPOP_SBC_1	132:136	AATSS	SPOP	0.6351	More...
Q08188	Protein-glutamine gamma-glutamyltransferase E	DEG_SPOP_SBC_1	467:471	AATSS	SPOP	0.503	More...
Q15345	Leucine-rich repeat-containing protein 41	DEG_SPOP_SBC_1	362:366	AATSS	SPOP	0.9096	More...
Q4LE39	AT-rich interactive domain-containing protein 4B	DEG_SPOP_SBC_1	1272:1276	AATSS	SPOP	0.8855	More...
Q5HY92	Fidgetin	DEG_SPOP_SBC_1	449:453	AATSS	SPOP	0.623	More...
Q75QN2	Integrator complex subunit 8	DEG_SPOP_SBC_1	10:14	AATSS	SPOP	0.8854	More...
Q7L2J0	7SK snRNA methylphosphate capping enzyme	DEG_SPOP_SBC_1	73:77	AATSS	SPOP	0.9873	More...
Q86V15	Zinc finger protein castor homolog 1	DEG_SPOP_SBC_1	217:221	AATSS	SPOP	0.9362	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	1067:1071	AATSS	SPOP	0.625	More...
Q99683	Mitogen-activated protein kinase kinase kinase 5	DEG_SPOP_SBC_1	69:73	AATSS	SPOP	0.9979	More...
Q9C0D5	Protein TANC1	DEG_SPOP_SBC_1	315:319	AATSS	SPOP	0.9995	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2727:2731	AATSS	SPOP	0.9343	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3427:3431	AATSS	SPOP	0.9499	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3984:3988	AATSS	SPOP	0.9705	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4717:4721	AATSS	SPOP	0.9583	More...
Q9HCD6	Protein TANC2	DEG_SPOP_SBC_1	270:274	AATSS	SPOP	0.7398	More...
Q9UNY4	Transcription termination factor 2	DEG_SPOP_SBC_1	347:351	AATSS	SPOP	0.8523	More...
Q9Y6C5	Protein patched homolog 2	DEG_SPOP_SBC_1	1186:1190	AATSS	SPOP	0.9776	More...
Q96M27	Protein PRRC1	DEG_SPOP_SBC_1	35:39	AATSS	SPOP	0.8538	More...
Q8TC56	Golgi associated RAB2 interactor protein 3	DEG_SPOP_SBC_1	225:229	AATSS	SPOP	0.8742	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	652:656	AATSS	SPOP	0.8671	More...
O43304	SEC14-like protein 5	DEG_SPOP_SBC_1	678:682	AATSS	SPOP	0.7971	More...
Q5JV73	FERM and PDZ domain-containing protein 3	DEG_SPOP_SBC_1	949:953	AATSS	SPOP	0.9369	More...
Q8TB05	UBA-like domain-containing protein 1	DEG_SPOP_SBC_1	114:118	AATSS	SPOP	0.6952	More...
Q9BXQ6	Transmembrane protein 121B	DEG_SPOP_SBC_1	117:121	AATSS	SPOP	0.9763	More...
Q9UNZ5	Leydig cell tumor 10 kDa protein homolog	DEG_SPOP_SBC_1	91:95	AATSS	SPOP	0.9522	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AATSS

Degron related mutations and impact score

Drug responses associated with GARIN3 mutations

All proteins holding degron of AATSS