DegronMD - Q15345(LRRC41)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R356L	TCGA-09-2044	OV	TCGA	AATSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.1667
p.R356L	DO28923	OV	ICGC	AATSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.1667
p.R356W	TCGA-DF-A2KU	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.1667
p.R356W	TCGA-E7-A541	BLCA	TCGA	AATSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.1667
p.R356W	DO44037	BLCA	ICGC	AATSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.1667
p.R356W	DO223286	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.1667
p.S368C	TCGA-E7-A7XN	BLCA	TCGA	ASSST	DEG_SPOP_SBC_1	367:371	Mutation altering degron motif	0.643
p.S368C	DO51878	BLCA	ICGC	ASSST	DEG_SPOP_SBC_1	367:371	Mutation altering degron motif	0.643
p.A377V	TCGA-F7-A623	HNSC	TCGA	ASSST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.1667
p.A377V	DO44443	HNSC	ICGC	ASSST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.1667
p.R376Q	TCGA-HU-A4GQ	STAD	TCGA	AATSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.0556
p.R376Q	TCGA-HU-A4GQ	STAD	TCGA	ASSST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.1944
p.R376Q	DO47767	STAD	ICGC	AATSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.0556
p.R376Q	DO47767	STAD	ICGC	ASSST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.1944
p.A362V	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	362:366	Mutation altering degron motif	0.5825
p.A362V	ACH-000766	Lung Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	362:366	Mutation altering degron motif	0.5825
p.A362V	NCI-H1648	lung	COSMIC	AATSS	DEG_SPOP_SBC_1	362:366	Mutation altering degron motif	0.5825
p.P361Q	SIDM00290	Gastric Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.3056
p.P361Q	SIDM00290	Gastric Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.1667
p.P361Q	ACH-000847	Gastric Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.3056
p.P361Q	ACH-000847	Gastric Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.1667
p.P361Q	HGC-27	stomach	COSMIC	AATSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.3056
p.P361Q	HGC-27	stomach	COSMIC	ASSST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.1667
p.T371A	ACH-001300	Neuroblastoma	CCLE	ASSST	DEG_SPOP_SBC_1	367:371	Mutation altering degron motif	0.7139
p.R368C	SNU-1040	large intestine	COSMIC	ASSST	DEG_SPOP_SBC_1	367:371	Mutation altering degron motif	0.8301
p.R379H	NY	bone	COSMIC	ASSST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.1111
p.R379H	NB5	autonomic ganglia	COSMIC	ASSST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.1111
p.R379C	EFO-21	ovary	COSMIC	ASSST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.1111
p.R379C	LS-411N	large intestine	COSMIC	ASSST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.1111
p.R381C	NCI-H1651	lung	COSMIC	ASSST	DEG_SPOP_SBC_1	367:371	Mutation rewiring degron network	0.0556
p.A352T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	AATSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.0556

Kaplan plot for LRRC41 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRC41

UniProt ID: Q15345

Entrez ID: 10489

Protein name: Leucine-rich repeat-containing protein 41 (Protein Muf1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRC41 in