DegronMD - Q9UNY4(TTF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D352G	TCGA-17-Z020	LUAD	TCGA	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.3056
p.T380M	TCGA-A5-A0G2	UCEC	TCGA	TKENL	DEG_APCC_KENBOX_2	380:384	Mutation altering degron motif	0.7423
p.T380M	DO229051	LICA	ICGC	TKENL	DEG_APCC_KENBOX_2	380:384	Mutation altering degron motif	0.7423
p.T380M	DO41235	UCEC	ICGC	TKENL	DEG_APCC_KENBOX_2	380:384	Mutation altering degron motif	0.7423
p.T380R	TCGA-D3-A2JL	SKCM	TCGA	TKENL	DEG_APCC_KENBOX_2	380:384	Mutation altering degron motif	0.7876
p.T380R	DO47278	SKCM	ICGC	TKENL	DEG_APCC_KENBOX_2	380:384	Mutation altering degron motif	0.7876
p.L341M	TCGA-D3-A2JP	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1667
p.L341M	DO47407	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1667
p.R345C	TCGA-EB-A41A	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.2778
p.R345C	TCGA-NH-A5IV	COAD	TCGA	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.2778
p.R345C	DO49095	COAD	ICGC	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.2778
p.R345C	DO37429	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.2778
p.R345C	SIDM01050	Biliary Tract Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.2778
p.R345C	ACH-001494	Bile Duct Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.2778
p.R345C	EGI-1	biliary tract	COSMIC	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.2778
p.L376M	TCGA-FI-A2D5	UCEC	TCGA	TKENL	DEG_APCC_KENBOX_2	380:384	Mutation rewiring degron network	0.2222
p.L376M	DO48440	BLCA	ICGC	TKENL	DEG_APCC_KENBOX_2	380:384	Mutation rewiring degron network	0.2222
p.L376M	DO41331	UCEC	ICGC	TKENL	DEG_APCC_KENBOX_2	380:384	Mutation rewiring degron network	0.2222
p.K381N	TCGA-FS-A1ZG	SKCM	TCGA	TKENL	DEG_APCC_KENBOX_2	380:384	Mutation altering degron motif	0.6918
p.K381N	DO37523	SKCM	ICGC	TKENL	DEG_APCC_KENBOX_2	380:384	Mutation altering degron motif	0.6918
p.L384P	DO228949	LICA	ICGC	TKENL	DEG_APCC_KENBOX_2	380:384	Mutation altering degron motif	0.6471
p.S340F	DO220882	MELA	ICGC	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1389
p.D353Y	DO232018	ORCA	ICGC	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.2778
p.R389Q	DO232761	PBCA	ICGC	TKENL	DEG_APCC_KENBOX_2	380:384	Mutation rewiring degron network	0.1944
p.T349A	SIDM01005	Acute Myeloid Leukemia	GDSC	AATSS	DEG_SPOP_SBC_1	347:351	Mutation altering degron motif	0.825
p.T349A	ACH-000263	Leukemia	CCLE	AATSS	DEG_SPOP_SBC_1	347:351	Mutation altering degron motif	0.825
p.T349A	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	AATSS	DEG_SPOP_SBC_1	347:351	Mutation altering degron motif	0.825
p.R345H	SIDM00142	Endometrial Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.2778
p.R345H	ACH-000864	Endometrial/Uterine Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.2778
p.R345H	COLO-684	endometrium	COSMIC	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.2778
p.P337T	SIDM01188	Pancreatic Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.0556
p.P337T	ACH-000114	Pancreatic Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.0556
p.P337T	SU8686	pancreas	COSMIC	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.0556
p.E355D	SIDM01133	Other Solid Cancers	GDSC	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.2222
p.E355D	ACH-002177	Lung Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.2222
p.E355D	NCI-H835	lung	COSMIC	AATSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.2222
p.N383T	ACH-000955	Colon/Colorectal Cancer	CCLE	TKENL	DEG_APCC_KENBOX_2	380:384	Mutation altering degron motif	0.7055
p.N383T	SNU-407	large intestine	COSMIC	TKENL	DEG_APCC_KENBOX_2	380:384	Mutation altering degron motif	0.7055

Kaplan plot for TTF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TTF2

UniProt ID: Q9UNY4

Entrez ID: 8458

Protein name: Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TTF2 in