DegronMD

Uniprot ID: Q9UNY4

Source protein: Transcription termination factor 2

Source gene: TTF2

Class: DEG_SPOP_SBC_1

Location: 347:351

E3 ligase: SPOP

DEGRON score: 0.8523

ASA_SCORE: 75.6

COIL: 0.842

CONS_SCORE: 0.2387

DSS_SCORE: 0.7666

HELIX: 0.1338

FCONS_SCORE: 0.9495

RIG_SCORE: 0.6124

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D352G	TCGA-17-Z020	LUAD	TCGA	AATSS	DEG_SPOP_SBC_1	0.3056
p.L341M	TCGA-D3-A2JP	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	0.1667
p.L341M	DO47407	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	0.1667
p.R345C	TCGA-EB-A41A	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	0.2778
p.R345C	TCGA-NH-A5IV	COAD	TCGA	AATSS	DEG_SPOP_SBC_1	0.2778
p.R345C	DO49095	COAD	ICGC	AATSS	DEG_SPOP_SBC_1	0.2778
p.R345C	DO37429	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	0.2778
p.R345C	SIDM01050	Biliary Tract Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	0.2778
p.R345C	ACH-001494	Bile Duct Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	0.2778
p.R345C	EGI-1	biliary_tract	COSMIC	AATSS	DEG_SPOP_SBC_1	0.2778
p.S340F	DO220882	MELA	ICGC	AATSS	DEG_SPOP_SBC_1	0.1389
p.D353Y	DO232018	ORCA	ICGC	AATSS	DEG_SPOP_SBC_1	0.2778
p.T349A	SIDM01005	Acute Myeloid Leukemia	GDSC	AATSS	DEG_SPOP_SBC_1	0.825
p.T349A	ACH-000263	Leukemia	CCLE	AATSS	DEG_SPOP_SBC_1	0.825
p.T349A	KASUMI-1	haematopoietic_and_lymphoid_tissue	COSMIC	AATSS	DEG_SPOP_SBC_1	0.825
p.R345H	SIDM00142	Endometrial Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	0.2778
p.R345H	ACH-000864	Endometrial/Uterine Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	0.2778
p.R345H	COLO-684	endometrium	COSMIC	AATSS	DEG_SPOP_SBC_1	0.2778
p.P337T	SIDM01188	Pancreatic Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	0.0556
p.P337T	ACH-000114	Pancreatic Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	0.0556
p.P337T	SU8686	pancreas	COSMIC	AATSS	DEG_SPOP_SBC_1	0.0556
p.E355D	SIDM01133	Other Solid Cancers	GDSC	AATSS	DEG_SPOP_SBC_1	0.2222
p.E355D	ACH-002177	Lung Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	0.2222
p.E355D	NCI-H835	lung	COSMIC	AATSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43166	Signal-induced proliferation-associated 1-like protein 1	DEG_SPOP_SBC_1	1345:1349	AATSS	SPOP	0.9959	More...
P30414	NK-tumor recognition protein	DEG_SPOP_SBC_1	1240:1244	AATSS	SPOP	0.574	More...
P51575	P2X purinoceptor 1	DEG_SPOP_SBC_1	384:388	AATSS	SPOP	0.9498	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3473:3477	AATSS	SPOP	0.9561	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3906:3910	AATSS	SPOP	0.9778	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4212:4216	AATSS	SPOP	0.9754	More...
Q02447	Transcription factor Sp3	DEG_SPOP_SBC_1	132:136	AATSS	SPOP	0.6351	More...
Q08188	Protein-glutamine gamma-glutamyltransferase E	DEG_SPOP_SBC_1	467:471	AATSS	SPOP	0.503	More...
Q15345	Leucine-rich repeat-containing protein 41	DEG_SPOP_SBC_1	362:366	AATSS	SPOP	0.9096	More...
Q4LE39	AT-rich interactive domain-containing protein 4B	DEG_SPOP_SBC_1	1272:1276	AATSS	SPOP	0.8855	More...
Q5HY92	Fidgetin	DEG_SPOP_SBC_1	449:453	AATSS	SPOP	0.623	More...
Q75QN2	Integrator complex subunit 8	DEG_SPOP_SBC_1	10:14	AATSS	SPOP	0.8854	More...
Q7L2J0	7SK snRNA methylphosphate capping enzyme	DEG_SPOP_SBC_1	73:77	AATSS	SPOP	0.9873	More...
Q86V15	Zinc finger protein castor homolog 1	DEG_SPOP_SBC_1	217:221	AATSS	SPOP	0.9362	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	1067:1071	AATSS	SPOP	0.625	More...
Q99683	Mitogen-activated protein kinase kinase kinase 5	DEG_SPOP_SBC_1	69:73	AATSS	SPOP	0.9979	More...
Q9C0D5	Protein TANC1	DEG_SPOP_SBC_1	315:319	AATSS	SPOP	0.9995	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2727:2731	AATSS	SPOP	0.9343	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3427:3431	AATSS	SPOP	0.9499	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3984:3988	AATSS	SPOP	0.9705	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4717:4721	AATSS	SPOP	0.9583	More...
Q9HCD6	Protein TANC2	DEG_SPOP_SBC_1	270:274	AATSS	SPOP	0.7398	More...
Q9UNY4	Transcription termination factor 2	DEG_SPOP_SBC_1	347:351	AATSS	SPOP	0.8523	More...
Q9Y6C5	Protein patched homolog 2	DEG_SPOP_SBC_1	1186:1190	AATSS	SPOP	0.9776	More...
Q96M27	Protein PRRC1	DEG_SPOP_SBC_1	35:39	AATSS	SPOP	0.8538	More...
Q8TC56	Golgi associated RAB2 interactor protein 3	DEG_SPOP_SBC_1	225:229	AATSS	SPOP	0.8742	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	652:656	AATSS	SPOP	0.8671	More...
O43304	SEC14-like protein 5	DEG_SPOP_SBC_1	678:682	AATSS	SPOP	0.7971	More...
Q5JV73	FERM and PDZ domain-containing protein 3	DEG_SPOP_SBC_1	949:953	AATSS	SPOP	0.9369	More...
Q8TB05	UBA-like domain-containing protein 1	DEG_SPOP_SBC_1	114:118	AATSS	SPOP	0.6952	More...
Q9BXQ6	Transmembrane protein 121B	DEG_SPOP_SBC_1	117:121	AATSS	SPOP	0.9763	More...
Q9UNZ5	Leydig cell tumor 10 kDa protein homolog	DEG_SPOP_SBC_1	91:95	AATSS	SPOP	0.9522	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AATSS

Degron related mutations and impact score

Drug responses associated with TTF2 mutations

All proteins holding degron of AATSS