DegronMD - O43304(SEC14L5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G686C	TCGA-21-5783	LUSC	TCGA	AATSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.2222
p.G686C	DO27437	LUSC	ICGC	AATSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.2222
p.G236R	TCGA-23-2078	OV	TCGA	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation rewiring degron network	0.2778
p.G236R	DO31829	OV	ICGC	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation rewiring degron network	0.2778
p.H689R	TCGA-44-6777	LUAD	TCGA	AATSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.1389
p.H689R	DO23645	LUAD	ICGC	AATSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.1389
p.S681L	TCGA-49-4490	LUAD	TCGA	AATSS	DEG_SPOP_SBC_1	678:682	Mutation altering degron motif	0.7667
p.S681L	DO24374	LUAD	ICGC	AATSS	DEG_SPOP_SBC_1	678:682	Mutation altering degron motif	0.7667
p.A678T	TCGA-A5-A0G2	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	678:682	Mutation altering degron motif	0.7139
p.A678T	DO228824	MALY	ICGC	AATSS	DEG_SPOP_SBC_1	678:682	Mutation altering degron motif	0.7139
p.A678T	DO41235	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	678:682	Mutation altering degron motif	0.7139
p.A678T	SIDM00517	Head and Neck Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	678:682	Mutation altering degron motif	0.7139
p.A678T	H3118	upper aerodigestive tract	COSMIC	AATSS	DEG_SPOP_SBC_1	678:682	Mutation altering degron motif	0.7139
p.E243D	TCGA-AP-A0LM	UCEC	TCGA	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation altering degron motif	0.6758
p.E243D	DO43306	UCEC	ICGC	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation altering degron motif	0.6758
p.M241I	TCGA-BS-A0UA	UCEC	TCGA	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation altering degron motif	0.6507
p.M241I	DO42552	UCEC	ICGC	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation altering degron motif	0.6507
p.A679T	TCGA-CD-A4MG	STAD	TCGA	AATSS	DEG_SPOP_SBC_1	678:682	Mutation altering degron motif	0.6028
p.A679T	DO48009	STAD	ICGC	AATSS	DEG_SPOP_SBC_1	678:682	Mutation altering degron motif	0.6028
p.S692F	TCGA-D3-A8GL	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.0556
p.S692F	DO50287	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.0556
p.R250W	TCGA-EI-6917	READ	TCGA	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation rewiring degron network	0.1389
p.R250W	DO36881	READ	ICGC	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation rewiring degron network	0.1389
p.R250W	ACH-001119	Lymphoma	CCLE	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation rewiring degron network	0.1389
p.P240H	TCGA-QQ-A8VF	SARC	TCGA	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation altering degron motif	0.7694
p.P240H	DO220258	SARC	ICGC	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation altering degron motif	0.7694
p.T239M	DO13192	GBM	ICGC	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation altering degron motif	0.7423
p.C669F	DO228952	LICA	ICGC	AATSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.0833
p.T680S	DO232846	NACA	ICGC	AATSS	DEG_SPOP_SBC_1	678:682	Mutation altering degron motif	0.6005
p.Q248L	DO46905	RECA	ICGC	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation rewiring degron network	0.1944
p.G236D	SIDM01293	Colorectal Carcinoma	GDSC	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation rewiring degron network	0.2778
p.L246M	SIDM01278	Colorectal Carcinoma	GDSC	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation rewiring degron network	0.25
p.C245F	SIDM02034	Colorectal Carcinoma	GDSC	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation rewiring degron network	0.2778
p.A678S	SIDM00013	Melanoma	GDSC	AATSS	DEG_SPOP_SBC_1	678:682	Mutation altering degron motif	0.7588
p.G686S	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.2222
p.G686S	H513	pleura	COSMIC	AATSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.2222
p.G686V	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.2222
p.G686V	H513	pleura	COSMIC	AATSS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.2222
p.I247T	SIDM01229	Neuroblastoma	GDSC	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation rewiring degron network	0.2222
p.I247T	ACH-000312	Neuroblastoma	CCLE	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation rewiring degron network	0.2222
p.I247T	ACH-002217	Neuroblastoma	CCLE	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation rewiring degron network	0.2222
p.I247T	BE2-M17	autonomic ganglia	COSMIC	LTPMQE	DEG_SCF_FBW7_2	238:243	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEC14L5

UniProt ID: O43304

Entrez ID: 9717

Protein name: SEC14-like protein 5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEC14L5 in