DegronMD

Uniprot ID: O43304

Source protein: SEC14-like protein 5

Source gene: SEC14L5

Class: DEG_SCF_FBW7_2

Location: 238:243

E3 ligase: FBXW7

DEGRON score: 0.854

ASA_SCORE: 50.4667

COIL: 0.3365

CONS_SCORE: 0.4927

DSS_SCORE: 0.1027

HELIX: 0.6532

FCONS_SCORE: 1.2603

RIG_SCORE: 0.801

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G236R	TCGA-23-2078	OV	TCGA	LTPMQE	DEG_SCF_FBW7_2	0.2778
p.G236R	DO31829	OV	ICGC	LTPMQE	DEG_SCF_FBW7_2	0.2778
p.E243D	TCGA-AP-A0LM	UCEC	TCGA	LTPMQE	DEG_SCF_FBW7_2	0.6758
p.E243D	DO43306	UCEC	ICGC	LTPMQE	DEG_SCF_FBW7_2	0.6758
p.M241I	TCGA-BS-A0UA	UCEC	TCGA	LTPMQE	DEG_SCF_FBW7_2	0.6507
p.M241I	DO42552	UCEC	ICGC	LTPMQE	DEG_SCF_FBW7_2	0.6507
p.R250W	TCGA-EI-6917	READ	TCGA	LTPMQE	DEG_SCF_FBW7_2	0.1389
p.R250W	DO36881	READ	ICGC	LTPMQE	DEG_SCF_FBW7_2	0.1389
p.R250W	ACH-001119	Lymphoma	CCLE	LTPMQE	DEG_SCF_FBW7_2	0.1389
p.P240H	TCGA-QQ-A8VF	SARC	TCGA	LTPMQE	DEG_SCF_FBW7_2	0.7694
p.P240H	DO220258	SARC	ICGC	LTPMQE	DEG_SCF_FBW7_2	0.7694
p.T239M	DO13192	GBM	ICGC	LTPMQE	DEG_SCF_FBW7_2	0.7423
p.Q248L	DO46905	RECA	ICGC	LTPMQE	DEG_SCF_FBW7_2	0.1944
p.G236D	SIDM01293	Colorectal Carcinoma	GDSC	LTPMQE	DEG_SCF_FBW7_2	0.2778
p.L246M	SIDM01278	Colorectal Carcinoma	GDSC	LTPMQE	DEG_SCF_FBW7_2	0.25
p.C245F	SIDM02034	Colorectal Carcinoma	GDSC	LTPMQE	DEG_SCF_FBW7_2	0.2778
p.I247T	SIDM01229	Neuroblastoma	GDSC	LTPMQE	DEG_SCF_FBW7_2	0.2222
p.I247T	ACH-000312	Neuroblastoma	CCLE	LTPMQE	DEG_SCF_FBW7_2	0.2222
p.I247T	ACH-002217	Neuroblastoma	CCLE	LTPMQE	DEG_SCF_FBW7_2	0.2222
p.I247T	BE2-M17	autonomic_ganglia	COSMIC	LTPMQE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43304	SEC14-like protein 5	DEG_SCF_FBW7_2	238:243	LTPMQE	FBXW7	0.854	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons