DegronMD - Q99683(MAP3K5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A889T	TCGA-86-A4JF	LUAD	TCGA	FKVHPE	LIG_APCC_ABBA_1	897:902	Mutation rewiring degron network	0.1111
p.P901L	TCGA-EE-A29E	SKCM	TCGA	FKVHPE	LIG_APCC_ABBA_1	897:902	Mutation altering degron motif	0.6471
p.S72Y	TCGA-G2-AA3B	BLCA	TCGA	AATSS	DEG_SPOP_SBC_1	69:73	Mutation altering degron motif	0.712
p.S72Y	DO51882	BLCA	ICGC	AATSS	DEG_SPOP_SBC_1	69:73	Mutation altering degron motif	0.712
p.R80Q	TCGA-L5-A4OI	ESCA	TCGA	AATSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1389
p.G71R	DO234304	ESAD	ICGC	AATSS	DEG_SPOP_SBC_1	69:73	Mutation altering degron motif	0.7568
p.T60I	DO223074	ESCA	ICGC	AATSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0833
p.K66N	DO18661	KIRC	ICGC	AATSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.25
p.T71P	DO49137	PACA	ICGC	AATSS	DEG_SPOP_SBC_1	69:73	Mutation altering degron motif	0.7031
p.T60A	DO41542	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0833
p.H900Y	SIDM00973	Melanoma	GDSC	FKVHPE	LIG_APCC_ABBA_1	897:902	Mutation altering degron motif	0.6118
p.H900Y	ACH-000827	Skin Cancer	CCLE	FKVHPE	LIG_APCC_ABBA_1	897:902	Mutation altering degron motif	0.6118
p.H900Y	WM793B	skin	COSMIC	FKVHPE	LIG_APCC_ABBA_1	897:902	Mutation altering degron motif	0.6118
p.K898E	SIDM00807	Bladder Carcinoma	GDSC	FKVHPE	LIG_APCC_ABBA_1	897:902	Mutation altering degron motif	0.591
p.K898E	ACH-000905	Bladder Cancer	CCLE	FKVHPE	LIG_APCC_ABBA_1	897:902	Mutation altering degron motif	0.591
p.K898E	5637	urinary tract	COSMIC	FKVHPE	LIG_APCC_ABBA_1	897:902	Mutation altering degron motif	0.591
p.S83C	SIDM00628	Breast Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	69:73	Mutation blocking phosphorylation signal	0.5
p.S83C	ACH-000849	Breast Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	69:73	Mutation blocking phosphorylation signal	0.5
p.S83C	MDA-MB-468	breast	COSMIC	AATSS	DEG_SPOP_SBC_1	69:73	Mutation blocking phosphorylation signal	0.5
p.R78Q	ACH-000973	Bladder Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1944

Kaplan plot for MAP3K5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP3K5

UniProt ID: Q99683

Entrez ID: 4217

Protein name: Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP3K5 in