DegronMD

Uniprot ID: Q99683

Source protein: Mitogen-activated protein kinase kinase kinase 5

Source gene: MAP3K5

Class: LIG_APCC_ABBA_1

Location: 897:902

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.682

ASA_SCORE: 85.55

COIL: 0.965

CONS_SCORE: 0.57

DSS_SCORE: 0.2203

HELIX: 0.0222

FCONS_SCORE: 1.0954

RIG_SCORE: 0.785

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A889T	TCGA-86-A4JF	LUAD	TCGA	FKVHPE	LIG_APCC_ABBA_1	0.1111
p.P901L	TCGA-EE-A29E	SKCM	TCGA	FKVHPE	LIG_APCC_ABBA_1	0.6471
p.H900Y	SIDM00973	Melanoma	GDSC	FKVHPE	LIG_APCC_ABBA_1	0.6118
p.H900Y	ACH-000827	Skin Cancer	CCLE	FKVHPE	LIG_APCC_ABBA_1	0.6118
p.H900Y	WM793B	skin	COSMIC	FKVHPE	LIG_APCC_ABBA_1	0.6118
p.K898E	SIDM00807	Bladder Carcinoma	GDSC	FKVHPE	LIG_APCC_ABBA_1	0.591
p.K898E	ACH-000905	Bladder Cancer	CCLE	FKVHPE	LIG_APCC_ABBA_1	0.591
p.K898E	5637	urinary_tract	COSMIC	FKVHPE	LIG_APCC_ABBA_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99683	Mitogen-activated protein kinase kinase kinase 5	LIG_APCC_ABBA_1	897:902	FKVHPE	APC,CDC20,FZR1	0.682	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons