DegronMD - Q75QN2(INTS8)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A11T	TCGA-5P-A9JU	KIRP	TCGA	AATSS	DEG_SPOP_SBC_1	10:14	Mutation altering degron motif	0.6028
p.A11T	DO223941	KIRP	ICGC	AATSS	DEG_SPOP_SBC_1	10:14	Mutation altering degron motif	0.6028
p.P19A	TCGA-ER-A19P	SKCM	TCGA	PCTPPQT	DEG_SCF_FBW7_1	16:22	Mutation altering degron motif	0.7503
p.P19A	DO47623	SKCM	ICGC	PCTPPQT	DEG_SCF_FBW7_1	16:22	Mutation altering degron motif	0.7503
p.E30V	DO227996	COCA	ICGC	PCTPPQT	DEG_SCF_FBW7_1	16:22	Mutation rewiring degron network	0.1111
p.T18P	DO218858	SKCA	ICGC	PCTPPQT	DEG_SCF_FBW7_1	16:22	Mutation altering degron motif	0.8142
p.T22N	DO229213	THCA	ICGC	PCTPPQT	DEG_SCF_FBW7_1	16:22	Mutation altering degron motif	0.8166
p.Q21H	DO229248	THCA	ICGC	PCTPPQT	DEG_SCF_FBW7_1	16:22	Mutation altering degron motif	0.647
p.Q21H	ACH-001674	Neuroblastoma	CCLE	PCTPPQT	DEG_SCF_FBW7_1	16:22	Mutation altering degron motif	0.647

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons