DegronMD

Uniprot ID: Q75QN2

Source protein: Integrator complex subunit 8

Source gene: INTS8

Class: DEG_SCF_FBW7_1

Location: 16:22

E3 ligase: FBXW7

DEGRON score: 0.9983

ASA_SCORE: 77.4429

COIL: 0.8899

CONS_SCORE: 0.3428

DSS_SCORE: 0.2902

HELIX: 0.027

FCONS_SCORE: 0.7049

RIG_SCORE: 0.7107

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T22N	DO229213	THCA	ICGC	PCTPPQT	DEG_SCF_FBW7_1	0.8166
p.T18P	DO218858	SKCA	ICGC	PCTPPQT	DEG_SCF_FBW7_1	0.8142
p.P19A	TCGA-ER-A19P	SKCM	TCGA	PCTPPQT	DEG_SCF_FBW7_1	0.7503
p.P19A	DO47623	SKCM	ICGC	PCTPPQT	DEG_SCF_FBW7_1	0.7503
p.Q21H	DO229248	THCA	ICGC	PCTPPQT	DEG_SCF_FBW7_1	0.647
p.Q21H	ACH-001674	Neuroblastoma	CCLE	PCTPPQT	DEG_SCF_FBW7_1	0.647
p.E30V	DO227996	COCA	ICGC	PCTPPQT	DEG_SCF_FBW7_1	0.1111

Showing 1 to 7 of 7 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q75QN2	Integrator complex subunit 8	DEG_SCF_FBW7_1	16:22	PCTPPQT	FBXW7	0.9983	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons