DegronMD - Q86V15(CASZ1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A218T	TCGA-12-3646	GBM	TCGA	AATSS	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.6028
p.A218T	TCGA-AP-A1DK	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.6028
p.A218T	DO12184	GBM	ICGC	AATSS	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.6028
p.A218T	DO42033	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.6028
p.D152G	TCGA-2W-A8YY	CESC	TCGA	DSGPST	DEG_SCF_TRCP1_1	159:164	Mutation rewiring degron network	0.1389
p.D152G	DO223732	CESC	ICGC	DSGPST	DEG_SCF_TRCP1_1	159:164	Mutation rewiring degron network	0.1389
p.S213P	TCGA-AM-5821	COAD	TCGA	AATSS	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.2222
p.S213P	DO8240	COAD	ICGC	AATSS	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.2222
p.D152V	TCGA-AZ-6598	COAD	TCGA	DSGPST	DEG_SCF_TRCP1_1	159:164	Mutation rewiring degron network	0.1389
p.D152V	DO10276	COAD	ICGC	DSGPST	DEG_SCF_TRCP1_1	159:164	Mutation rewiring degron network	0.1389
p.A211T	TCGA-B5-A1MX	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1667
p.A211T	DO33256	PACA	ICGC	AATSS	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1667
p.A211T	DO41999	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1667
p.P224L	TCGA-DA-A95Z	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.25
p.P224L	DO219481	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.25
p.E912K	TCGA-DI-A1BU	UCEC	TCGA	FPPAQVKPE	DEG_SIAH_1	904:912	Mutation altering degron motif	0.591
p.E912K	DO42023	UCEC	ICGC	FPPAQVKPE	DEG_SIAH_1	904:912	Mutation altering degron motif	0.591
p.S221Y	TCGA-DU-7298	LGG	TCGA	AATSS	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.712
p.S221Y	DO22679	LGG	ICGC	AATSS	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.712
p.S213Y	TCGA-ER-A19P	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.2222
p.S213Y	DO47623	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.2222
p.R165M	TCGA-L5-A43J	ESCA	TCGA	DSGPST	DEG_SCF_TRCP1_1	159:164	Mutation rewiring degron network	0.3056
p.A171T	TCGA-L9-A8F4	LUAD	TCGA	DSGPST	DEG_SCF_TRCP1_1	159:164	Mutation rewiring degron network	0.1389
p.A171T	DO49876	LUAD	ICGC	DSGPST	DEG_SCF_TRCP1_1	159:164	Mutation rewiring degron network	0.1389
p.G921V	DO234164	ESAD	ICGC	FPPAQVKPE	DEG_SIAH_1	904:912	Mutation rewiring degron network	0.0833
p.Q898K	DO228974	LICA	ICGC	FPPAQVKPE	DEG_SIAH_1	904:912	Mutation rewiring degron network	0.1667
p.T229N	DO229009	LICA	ICGC	AATSS	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1111
p.P905L	DO222546	MELA	ICGC	FPPAQVKPE	DEG_SIAH_1	904:912	Mutation altering degron motif	0.7582
p.R903S	DO229234	THCA	ICGC	FPPAQVKPE	DEG_SIAH_1	904:912	Mutation rewiring degron network	0.3056
p.P911T	DO229245	THCA	ICGC	FPPAQVKPE	DEG_SIAH_1	904:912	Mutation altering degron motif	0.7031
p.S173L	SIDM00373	Endometrial Carcinoma	GDSC	DSGPST	DEG_SCF_TRCP1_1	159:164	Mutation rewiring degron network	0.0833
p.S173L	ACH-000974	Endometrial/Uterine Cancer	CCLE	DSGPST	DEG_SCF_TRCP1_1	159:164	Mutation rewiring degron network	0.0833
p.P922L	SIDM00336	Melanoma	GDSC	FPPAQVKPE	DEG_SIAH_1	904:912	Mutation rewiring degron network	0.0556
p.P922L	ACH-000881	Skin Cancer	CCLE	FPPAQVKPE	DEG_SIAH_1	904:912	Mutation rewiring degron network	0.0556
p.A154T	SIDM00284	Melanoma	GDSC	DSGPST	DEG_SCF_TRCP1_1	159:164	Mutation rewiring degron network	0.1944
p.A154T	COLO-679	skin	COSMIC	DSGPST	DEG_SCF_TRCP1_1	159:164	Mutation rewiring degron network	0.1944
p.E216D	SIDM01619	Endometrial Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.3056
p.E216D	ACH-000984	Endometrial/Uterine Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.3056
p.D152E	ACH-000945	Lung Cancer	CCLE	DSGPST	DEG_SCF_TRCP1_1	159:164	Mutation rewiring degron network	0.1389
p.P911L	ACH-001518	Endometrial/Uterine Cancer	CCLE	FPPAQVKPE	DEG_SIAH_1	904:912	Mutation altering degron motif	0.7582

Kaplan plot for CASZ1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CASZ1

UniProt ID: Q86V15

Entrez ID: 54897

Protein name: Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CASZ1 in