DegronMD

Uniprot ID: Q86V15

Source protein: Zinc finger protein castor homolog 1

Source gene: CASZ1

Class: DEG_SCF_TRCP1_1

Location: 159:164

E3 ligase: BTRC

DEGRON score: 0.9514

ASA_SCORE: 76.2833

COIL: 0.8858

CONS_SCORE: 0.4115

DSS_SCORE: 0.7445

HELIX: 0.0763

FCONS_SCORE: 0.8734

RIG_SCORE: 0.5519

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D152G	TCGA-2W-A8YY	CESC	TCGA	DSGPST	DEG_SCF_TRCP1_1	0.1389
p.D152G	DO223732	CESC	ICGC	DSGPST	DEG_SCF_TRCP1_1	0.1389
p.D152V	TCGA-AZ-6598	COAD	TCGA	DSGPST	DEG_SCF_TRCP1_1	0.1389
p.D152V	DO10276	COAD	ICGC	DSGPST	DEG_SCF_TRCP1_1	0.1389
p.R165M	TCGA-L5-A43J	ESCA	TCGA	DSGPST	DEG_SCF_TRCP1_1	0.3056
p.A171T	TCGA-L9-A8F4	LUAD	TCGA	DSGPST	DEG_SCF_TRCP1_1	0.1389
p.A171T	DO49876	LUAD	ICGC	DSGPST	DEG_SCF_TRCP1_1	0.1389
p.S173L	SIDM00373	Endometrial Carcinoma	GDSC	DSGPST	DEG_SCF_TRCP1_1	0.0833
p.S173L	ACH-000974	Endometrial/Uterine Cancer	CCLE	DSGPST	DEG_SCF_TRCP1_1	0.0833
p.A154T	SIDM00284	Melanoma	GDSC	DSGPST	DEG_SCF_TRCP1_1	0.1944
p.A154T	COLO-679	skin	COSMIC	DSGPST	DEG_SCF_TRCP1_1	0.1944
p.D152E	ACH-000945	Lung Cancer	CCLE	DSGPST	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86V15	Zinc finger protein castor homolog 1	DEG_SCF_TRCP1_1	159:164	DSGPST	BTRC	0.9514	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons