DegronMD

Uniprot ID: Q86V15

Source protein: Zinc finger protein castor homolog 1

Source gene: CASZ1

Class: DEG_SIAH_1

Location: 904:912

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.937

ASA_SCORE: 92.4222

COIL: 0.9319

CONS_SCORE: 0.4807

DSS_SCORE: 0.8037

HELIX: 0.0154

FCONS_SCORE: 1.2845

RIG_SCORE: 0.6082

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E912K	TCGA-DI-A1BU	UCEC	TCGA	FPPAQVKPE	DEG_SIAH_1	0.591
p.E912K	DO42023	UCEC	ICGC	FPPAQVKPE	DEG_SIAH_1	0.591
p.G921V	DO234164	ESAD	ICGC	FPPAQVKPE	DEG_SIAH_1	0.0833
p.Q898K	DO228974	LICA	ICGC	FPPAQVKPE	DEG_SIAH_1	0.1667
p.P905L	DO222546	MELA	ICGC	FPPAQVKPE	DEG_SIAH_1	0.7582
p.R903S	DO229234	THCA	ICGC	FPPAQVKPE	DEG_SIAH_1	0.3056
p.P911T	DO229245	THCA	ICGC	FPPAQVKPE	DEG_SIAH_1	0.7031
p.P922L	SIDM00336	Melanoma	GDSC	FPPAQVKPE	DEG_SIAH_1	0.0556
p.P922L	ACH-000881	Skin Cancer	CCLE	FPPAQVKPE	DEG_SIAH_1	0.0556
p.P911L	ACH-001518	Endometrial/Uterine Cancer	CCLE	FPPAQVKPE	DEG_SIAH_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86V15	Zinc finger protein castor homolog 1	DEG_SIAH_1	904:912	FPPAQVKPE	SIAH1,SIAH2,SIAH3	0.937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons