DegronMD - Q7L2J0(MEPCE)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R363H	TCGA-2W-A8YY	CESC	TCGA	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.2222
p.R363H	DO223732	CESC	ICGC	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.2222
p.S369Y	TCGA-63-A5MM	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation blocking phosphorylation signal	0.5
p.S369Y	DO219153	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation blocking phosphorylation signal	0.5
p.R363C	TCGA-CV-A6K2	HNSC	TCGA	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.2222
p.R363C	TCGA-GM-A3XL	BRCA	TCGA	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.2222
p.R363C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.2222
p.R363C	ACH-001127	Leukemia	CCLE	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.2222
p.R363C	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.2222
p.R366H	TCGA-D5-6931	COAD	TCGA	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389
p.R366H	DO8384	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389
p.R361Q	TCGA-GU-A42Q	BLCA	TCGA	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.2778
p.R361Q	DO485	BLCA	ICGC	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.2778
p.R366C	TCGA-UC-A7PG	CESC	TCGA	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389
p.R27C	DO9708	COAD	ICGC	VPPHQE	LIG_APCC_ABBA_1	32:37	Mutation rewiring degron network	0.1944
p.D22Y	DO230328	COCA	ICGC	VPPHQE	LIG_APCC_ABBA_1	32:37	Mutation rewiring degron network	0.0556
p.D22Y	DO232051	ORCA	ICGC	VPPHQE	LIG_APCC_ABBA_1	32:37	Mutation rewiring degron network	0.0556
p.A67D	DO14974	HNSC	ICGC	AATSS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.1667
p.A38D	DO228212	LICA	ICGC	VPPHQE	LIG_APCC_ABBA_1	32:37	Mutation rewiring degron network	0.3056
p.A348S	DO229029	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389
p.G66C	DO229038	LICA	ICGC	AATSS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.1389
p.R27H	DO219784	UCEC	ICGC	VPPHQE	LIG_APCC_ABBA_1	32:37	Mutation rewiring degron network	0.1944
p.A348D	SIDM00789	Colorectal Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389
p.A348D	HCT-15	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389
p.S358F	SIDM01096	Colorectal Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.9093
p.S358F	SK-CO-1	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.9093
p.A345G	SIDM00286	Neuroblastoma	GDSC	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.0556
p.A345G	ACH-000136	Neuroblastoma	CCLE	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.0556
p.A345G	CHP-126	autonomic ganglia	COSMIC	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.0556
p.H362Y	SIDM00660	Colorectal Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.25
p.H362Y	ACH-000985	Colon/Colorectal Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.25
p.H362Y	LS-411N	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.25
p.S359F	SIDM00704	Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.7982
p.S359F	ACH-000639	Lung Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.7982
p.S359F	NCI-H211	lung	COSMIC	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.7982
p.Q36R	ACH-000743	Lung Cancer	CCLE	VPPHQE	LIG_APCC_ABBA_1	32:37	Mutation altering degron motif	0.6218
p.V32A	ACH-000942	Leukemia	CCLE	VPPHQE	LIG_APCC_ABBA_1	32:37	Mutation altering degron motif	0.6936
p.R361L	ACH-001395	Breast Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.2778
p.Q69K	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	AATSS	DEG_SPOP_SBC_1	73:77	Mutation blocking phosphorylation signal	0.6667
p.F86L	GR-ST	haematopoietic and lymphoid tissue	COSMIC	AATSS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.0833
p.G63C	MFE-319	endometrium	COSMIC	AATSS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.0556
p.A39T	NCI-H446	lung	COSMIC	VPPHQE	LIG_APCC_ABBA_1	32:37	Mutation rewiring degron network	0.2778

Kaplan plot for MEPCE in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MEPCE

UniProt ID: Q7L2J0

Entrez ID: 56257

Protein name: 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MEPCE in