DegronMD

Uniprot ID: Q7L2J0

Source protein: 7SK snRNA methylphosphate capping enzyme

Source gene: MEPCE

Class: LIG_APCC_ABBA_1

Location: 32:37

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9037

ASA_SCORE: 99.6333

COIL: 0.7542

CONS_SCORE: 0.3102

DSS_SCORE: 0.8264

HELIX: 0.2417

FCONS_SCORE: 1.0447

RIG_SCORE: 0.6235

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R27C	DO9708	COAD	ICGC	VPPHQE	LIG_APCC_ABBA_1	0.1944
p.D22Y	DO230328	COCA	ICGC	VPPHQE	LIG_APCC_ABBA_1	0.0556
p.D22Y	DO232051	ORCA	ICGC	VPPHQE	LIG_APCC_ABBA_1	0.0556
p.A38D	DO228212	LICA	ICGC	VPPHQE	LIG_APCC_ABBA_1	0.3056
p.R27H	DO219784	UCEC	ICGC	VPPHQE	LIG_APCC_ABBA_1	0.1944
p.Q36R	ACH-000743	Lung Cancer	CCLE	VPPHQE	LIG_APCC_ABBA_1	0.6218
p.V32A	ACH-000942	Leukemia	CCLE	VPPHQE	LIG_APCC_ABBA_1	0.6936
p.A39T	NCI-H446	lung	COSMIC	VPPHQE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L2J0	7SK snRNA methylphosphate capping enzyme	LIG_APCC_ABBA_1	32:37	VPPHQE	APC,CDC20,FZR1	0.9037	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons