DegronMD - Q4LE39(ARID4B)

FUNCTION: Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic mod... View more >>

GO - Biological processes (BP): establishment of Sertoli cell barrier [GO:0097368]; histone H3-K9 trimethylation [GO:0036124]; histone H4-K20 trimethylation [GO:0034773]; negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by... View more >>

GO - Molecular function (MF): transcription cis-regulatory region binding [GO:0000976]

GO - Cellular component (CC): cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
RKENI	DEG_APCC_KENBOX_2	APC,CDC20,FZR1	AT-rich interactive domain-containing protein 4B	461:465	More..
VLNTPPTT	DEG_SCF_FBW7_1	FBXW7	AT-rich interactive domain-containing protein 4B	1019:1026	More..
VSSSS	DEG_SPOP_SBC_1	SPOP	AT-rich interactive domain-containing protein 4B	1096:1100	More..
AATSS	DEG_SPOP_SBC_1	SPOP	AT-rich interactive domain-containing protein 4B	1272:1276	More..
PSSSS	DEG_SPOP_SBC_1	SPOP	AT-rich interactive domain-containing protein 4B	1281:1285	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1099R	DO229029	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.7427
p.S1099R	DO229027	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.7427
p.E463G	SIDM01044	Other Solid Cancers	GDSC	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7199
p.E463G	ACH-000585	Lung Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7199
p.E463G	EPLC-272H	lung	COSMIC	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7199
p.A1026T	HCT-15	large intestine	COSMIC	VLNTPPTT	DEG_SCF_FBW7_1	1019:1026	Mutation altering degron motif	0.7139
p.S1283P	TCGA-B5-A3FA	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	1281:1285	Mutation altering degron motif	0.6752
p.S1283P	DO52402	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	1281:1285	Mutation altering degron motif	0.6752
p.S1097R	DO229036	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.6316
p.I465V	SIDM01608	Endometrial Carcinoma	GDSC	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.5965
p.I465V	ACH-000990	Endometrial/Uterine Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.5965
p.N1021K	TCGA-AA-A00N	COAD	TCGA	VLNTPPTT	DEG_SCF_FBW7_1	1019:1026	Mutation altering degron motif	0.5806
p.N1021K	DO9876	COAD	ICGC	VLNTPPTT	DEG_SCF_FBW7_1	1019:1026	Mutation altering degron motif	0.5806
p.S1271R	TCGA-EO-A3AZ	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	1272:1276	Mutation rewiring degron network	0.3056
p.S1271R	DO50078	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	1272:1276	Mutation rewiring degron network	0.3056
p.E460K	TCGA-GV-A3JZ	BLCA	TCGA	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.3056
p.E460K	DO773	BLCA	ICGC	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.3056
p.E460Q	TCGA-YC-A9TC	BLCA	TCGA	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.3056
p.E460Q	DO51949	BLCA	ICGC	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.3056
p.P1027T	DO229018	LICA	ICGC	VLNTPPTT	DEG_SCF_FBW7_1	1019:1026	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 44 entries

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No resistance data available for this Degron.

Kaplan plot for ARID4B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARID4B

UniProt ID: Q4LE39

Entrez ID: 51742

Protein name: AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for ARID4B in