DegronMD - Q4LE39(ARID4B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M1291I	TCGA-18-3415	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.1667
p.M1291I	DO26427	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.1667
p.N1102S	TCGA-24-1464	OV	TCGA	VSSSS	DEG_SPOP_SBC_1	1096:1100	Mutation rewiring degron network	0.2778
p.N1102S	DO29418	OV	ICGC	VSSSS	DEG_SPOP_SBC_1	1096:1100	Mutation rewiring degron network	0.2778
p.S1088L	TCGA-AA-3984	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	1096:1100	Mutation rewiring degron network	0.1111
p.S1088L	DO9002	COAD	ICGC	VSSSS	DEG_SPOP_SBC_1	1096:1100	Mutation rewiring degron network	0.1111
p.N1021K	TCGA-AA-A00N	COAD	TCGA	VLNTPPTT	DEG_SCF_FBW7_1	1019:1026	Mutation altering degron motif	0.5806
p.N1021K	DO9876	COAD	ICGC	VLNTPPTT	DEG_SCF_FBW7_1	1019:1026	Mutation altering degron motif	0.5806
p.F1011I	TCGA-B1-A657	KIRP	TCGA	VLNTPPTT	DEG_SCF_FBW7_1	1019:1026	Mutation rewiring degron network	0.1111
p.F1011I	DO51552	KIRP	ICGC	VLNTPPTT	DEG_SCF_FBW7_1	1019:1026	Mutation rewiring degron network	0.1111
p.S1283P	TCGA-B5-A3FA	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	1281:1285	Mutation altering degron motif	0.6752
p.S1283P	DO52402	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	1281:1285	Mutation altering degron motif	0.6752
p.R1263H	TCGA-EO-A22U	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	1272:1276	Mutation rewiring degron network	0.0833
p.R1263H	DO43755	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	1272:1276	Mutation rewiring degron network	0.0833
p.S1271R	TCGA-EO-A3AZ	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	1272:1276	Mutation rewiring degron network	0.3056
p.S1271R	TCGA-EO-A3AZ	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.0556
p.S1271R	DO50078	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	1272:1276	Mutation rewiring degron network	0.3056
p.S1271R	DO50078	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.0556
p.A1288T	TCGA-GC-A3I6	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.25
p.A1288T	DO844	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.25
p.E460K	TCGA-GV-A3JZ	BLCA	TCGA	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.3056
p.E460K	DO773	BLCA	ICGC	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.3056
p.R1263C	TCGA-VR-AA4D	ESCA	TCGA	AATSS	DEG_SPOP_SBC_1	1272:1276	Mutation rewiring degron network	0.0833
p.R1263C	DO232761	PBCA	ICGC	AATSS	DEG_SPOP_SBC_1	1272:1276	Mutation rewiring degron network	0.0833
p.E460Q	TCGA-YC-A9TC	BLCA	TCGA	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.3056
p.E460Q	DO51949	BLCA	ICGC	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.3056
p.L1294S	TCGA-ZD-A8I3	CHOL	TCGA	PSSSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.0833
p.D1093H	DO233262	GACA	ICGC	VSSSS	DEG_SPOP_SBC_1	1096:1100	Mutation rewiring degron network	0.25
p.P454T	DO229018	LICA	ICGC	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1389
p.P1027T	DO229018	LICA	ICGC	VLNTPPTT	DEG_SCF_FBW7_1	1019:1026	Mutation rewiring degron network	0.3056
p.S1099R	DO229029	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.7427
p.S1099R	DO229027	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.7427
p.S1097R	DO229036	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.6316
p.P1104Q	DO229036	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	1096:1100	Mutation rewiring degron network	0.2222
p.A1289V	DO232224	PBCA	ICGC	PSSSS	DEG_SPOP_SBC_1	1281:1285	Mutation rewiring degron network	0.2222
p.E463G	SIDM01044	Other Solid Cancers	GDSC	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7199
p.E463G	ACH-000585	Lung Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7199
p.E463G	EPLC-272H	lung	COSMIC	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7199
p.I459V	SIDM00679	Cervical Carcinoma	GDSC	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.2778
p.I459V	ACH-001525	Cervical Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.2778
p.I459V	HT-3	cervix	COSMIC	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.2778
p.I465V	SIDM01608	Endometrial Carcinoma	GDSC	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.5965
p.I465V	ACH-000990	Endometrial/Uterine Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.5965
p.A1026T	HCT-15	large intestine	COSMIC	VLNTPPTT	DEG_SCF_FBW7_1	1019:1026	Mutation altering degron motif	0.7139

Kaplan plot for ARID4B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARID4B

UniProt ID: Q4LE39

Entrez ID: 51742

Protein name: AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARID4B in