DegronMD

Uniprot ID: Q4LE39

Source protein: AT-rich interactive domain-containing protein 4B

Source gene: ARID4B

Class: DEG_SCF_FBW7_1

Location: 1019:1026

E3 ligase: FBXW7

DEGRON score: 0.9981

ASA_SCORE: 97.4375

COIL: 0.9598

CONS_SCORE: 0.5704

DSS_SCORE: 0.7131

HELIX: 0.0238

FCONS_SCORE: 1.3746

RIG_SCORE: 0.5796

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1021K	TCGA-AA-A00N	COAD	TCGA	VLNTPPTT	DEG_SCF_FBW7_1	0.5806
p.N1021K	DO9876	COAD	ICGC	VLNTPPTT	DEG_SCF_FBW7_1	0.5806
p.F1011I	TCGA-B1-A657	KIRP	TCGA	VLNTPPTT	DEG_SCF_FBW7_1	0.1111
p.F1011I	DO51552	KIRP	ICGC	VLNTPPTT	DEG_SCF_FBW7_1	0.1111
p.P1027T	DO229018	LICA	ICGC	VLNTPPTT	DEG_SCF_FBW7_1	0.3056
p.A1026T	HCT-15	large_intestine	COSMIC	VLNTPPTT	DEG_SCF_FBW7_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4LE39	AT-rich interactive domain-containing protein 4B	DEG_SCF_FBW7_1	1019:1026	VLNTPPTT	FBXW7	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons