DegronMD

Uniprot ID: Q4LE39

Source protein: AT-rich interactive domain-containing protein 4B

Source gene: ARID4B

Class: DEG_APCC_KENBOX_2

Location: 461:465

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9638

ASA_SCORE: 113.1

COIL: 0.57

CONS_SCORE: 0.3413

DSS_SCORE: 0.5464

HELIX: 0.3888

FCONS_SCORE: 1.0776

RIG_SCORE: 0.7148

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E460K	TCGA-GV-A3JZ	BLCA	TCGA	RKENI	DEG_APCC_KENBOX_2	0.3056
p.E460K	DO773	BLCA	ICGC	RKENI	DEG_APCC_KENBOX_2	0.3056
p.E460Q	TCGA-YC-A9TC	BLCA	TCGA	RKENI	DEG_APCC_KENBOX_2	0.3056
p.E460Q	DO51949	BLCA	ICGC	RKENI	DEG_APCC_KENBOX_2	0.3056
p.P454T	DO229018	LICA	ICGC	RKENI	DEG_APCC_KENBOX_2	0.1389
p.E463G	SIDM01044	Other Solid Cancers	GDSC	RKENI	DEG_APCC_KENBOX_2	0.7199
p.E463G	ACH-000585	Lung Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	0.7199
p.E463G	EPLC-272H	lung	COSMIC	RKENI	DEG_APCC_KENBOX_2	0.7199
p.I459V	SIDM00679	Cervical Carcinoma	GDSC	RKENI	DEG_APCC_KENBOX_2	0.2778
p.I459V	ACH-001525	Cervical Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	0.2778
p.I459V	HT-3	cervix	COSMIC	RKENI	DEG_APCC_KENBOX_2	0.2778
p.I465V	SIDM01608	Endometrial Carcinoma	GDSC	RKENI	DEG_APCC_KENBOX_2	0.5965
p.I465V	ACH-000990	Endometrial/Uterine Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43166	Signal-induced proliferation-associated 1-like protein 1	DEG_APCC_KENBOX_2	86:90	RKENI	APC,CDC20,FZR1	0.9334	More...
Q4LE39	AT-rich interactive domain-containing protein 4B	DEG_APCC_KENBOX_2	461:465	RKENI	APC,CDC20,FZR1	0.9638	More...
Q5T5P2	Sickle tail protein homolog	DEG_APCC_KENBOX_2	1075:1079	RKENI	APC,CDC20,FZR1	0.9909	More...
Q8N7X0	Androglobin	DEG_APCC_KENBOX_2	1508:1512	RKENI	APC,CDC20,FZR1	0.8902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons