DegronMD

Uniprot ID: O43166

Source protein: Signal-induced proliferation-associated 1-like protein 1

Source gene: SIPA1L1

Class: DEG_APCC_KENBOX_2

Location: 86:90

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9334

ASA_SCORE: 84.94

COIL: 0.7578

CONS_SCORE: 0.3756

DSS_SCORE: 0.6124

HELIX: 0.1648

FCONS_SCORE: 0.9821

RIG_SCORE: 0.7166

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V76I	TCGA-AX-A2HC	UCEC	TCGA	RKENI	DEG_APCC_KENBOX_2	0.0556
p.V76I	DO41572	UCEC	ICGC	RKENI	DEG_APCC_KENBOX_2	0.0556
p.E92K	TCGA-D1-A16X	UCEC	TCGA	RKENI	DEG_APCC_KENBOX_2	0.2778
p.E92K	DO41799	UCEC	ICGC	RKENI	DEG_APCC_KENBOX_2	0.2778
p.R86K	TCGA-EE-A2MN	SKCM	TCGA	RKENI	DEG_APCC_KENBOX_2	0.6126
p.R86K	DO222438	MELA	ICGC	RKENI	DEG_APCC_KENBOX_2	0.6126
p.R86K	DO37423	SKCM	ICGC	RKENI	DEG_APCC_KENBOX_2	0.6126
p.V76A	TCGA-MA-AA42	CESC	TCGA	RKENI	DEG_APCC_KENBOX_2	0.0556
p.V76A	DO219724	CESC	ICGC	RKENI	DEG_APCC_KENBOX_2	0.0556
p.R95H	DO233168	GACA	ICGC	RKENI	DEG_APCC_KENBOX_2	0.1944
p.R95H	ACH-001515	Cervical Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	0.1944
p.P85S	DO222843	MELA	ICGC	RKENI	DEG_APCC_KENBOX_2	0.3056
p.S94I	SIDM00279	Gastric Carcinoma	GDSC	RKENI	DEG_APCC_KENBOX_2	0.2222
p.S94I	ACH-000225	Gastric Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	0.2222
p.S94I	ECC12	stomach	COSMIC	RKENI	DEG_APCC_KENBOX_2	0.2222
p.N83K	NCI-H740	lung	COSMIC	RKENI	DEG_APCC_KENBOX_2	0.25
p.E100K	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	RKENI	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43166	Signal-induced proliferation-associated 1-like protein 1	DEG_APCC_KENBOX_2	86:90	RKENI	APC,CDC20,FZR1	0.9334	More...
Q4LE39	AT-rich interactive domain-containing protein 4B	DEG_APCC_KENBOX_2	461:465	RKENI	APC,CDC20,FZR1	0.9638	More...
Q5T5P2	Sickle tail protein homolog	DEG_APCC_KENBOX_2	1075:1079	RKENI	APC,CDC20,FZR1	0.9909	More...
Q8N7X0	Androglobin	DEG_APCC_KENBOX_2	1508:1512	RKENI	APC,CDC20,FZR1	0.8902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons