DegronMD - Q8N7X0(ADGB)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1516S	TCGA-A5-A0G1	UCEC	TCGA	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation rewiring degron network	0.2222
p.P1516S	DO42472	UCEC	ICGC	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation rewiring degron network	0.2222
p.R1517C	TCGA-AP-A1DO	UCEC	TCGA	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation rewiring degron network	0.1944
p.R1517C	DO233281	GACA	ICGC	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation rewiring degron network	0.1944
p.R1517C	DO51464	PACA	ICGC	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation rewiring degron network	0.1944
p.R1517C	DO43250	UCEC	ICGC	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation rewiring degron network	0.1944
p.R1519L	DO50828	LICA	ICGC	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation rewiring degron network	0.1389
p.R1508W	SIDM01307	Colorectal Carcinoma	GDSC	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation altering degron motif	0.7523
p.R1508W	SIDM00619	Thyroid Gland Carcinoma	GDSC	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation altering degron motif	0.7523
p.R1508W	KMH-2	thyroid	COSMIC	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation altering degron motif	0.7523
p.R1517H	SIDM00121	T-Lymphoblastic Leukemia	GDSC	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation rewiring degron network	0.1944
p.R1517H	ACH-000608	Ovarian Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation rewiring degron network	0.1944
p.R1517H	ACH-001738	Leukemia	CCLE	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation rewiring degron network	0.1944
p.R1517H	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation rewiring degron network	0.1944
p.P1521S	SIDM01064	Hodgkin's Lymphoma	GDSC	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation rewiring degron network	0.0833
p.P1521S	ACH-000267	Lymphoma	CCLE	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation rewiring degron network	0.0833
p.P1521S	HDLM-2	haematopoietic and lymphoid tissue	COSMIC	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation rewiring degron network	0.0833
p.R1503C	SIDM00451	T-Lymphoblastic Leukemia	GDSC	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation rewiring degron network	0.1944
p.R1503C	PF-382	haematopoietic and lymphoid tissue	COSMIC	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation rewiring degron network	0.1944
p.E1510K	SIDM01059	Melanoma	GDSC	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation altering degron motif	0.7022
p.E1510K	ACH-000915	Skin Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation altering degron motif	0.7022
p.E1510K	IPC-298	skin	COSMIC	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation altering degron motif	0.7022
p.K1509T	ACH-001001	Bone Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation altering degron motif	0.7306
p.T1522K	ACH-001611	Brain Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation blocking phosphorylation signal	0.5
p.R1519Q	ACH-001863	Bile Duct Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	1508:1512	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADGB

UniProt ID: Q8N7X0

Entrez ID: 79747

Protein name: Androglobin (Calpain-7-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADGB in