DegronMD

Uniprot ID: Q8N7X0

Source protein: Androglobin

Source gene: ADGB

Class: DEG_APCC_KENBOX_2

Location: 1508:1512

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8902

ASA_SCORE: 112.7

COIL: 0.555

CONS_SCORE: 0.2437

DSS_SCORE: 0.7961

HELIX: 0.435

FCONS_SCORE: 0.9866

RIG_SCORE: 0.6532

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1516S	TCGA-A5-A0G1	UCEC	TCGA	RKENI	DEG_APCC_KENBOX_2	0.2222
p.P1516S	DO42472	UCEC	ICGC	RKENI	DEG_APCC_KENBOX_2	0.2222
p.R1517C	TCGA-AP-A1DO	UCEC	TCGA	RKENI	DEG_APCC_KENBOX_2	0.1944
p.R1517C	DO233281	GACA	ICGC	RKENI	DEG_APCC_KENBOX_2	0.1944
p.R1517C	DO51464	PACA	ICGC	RKENI	DEG_APCC_KENBOX_2	0.1944
p.R1517C	DO43250	UCEC	ICGC	RKENI	DEG_APCC_KENBOX_2	0.1944
p.R1519L	DO50828	LICA	ICGC	RKENI	DEG_APCC_KENBOX_2	0.1389
p.R1508W	SIDM01307	Colorectal Carcinoma	GDSC	RKENI	DEG_APCC_KENBOX_2	0.7523
p.R1508W	SIDM00619	Thyroid Gland Carcinoma	GDSC	RKENI	DEG_APCC_KENBOX_2	0.7523
p.R1508W	KMH-2	thyroid	COSMIC	RKENI	DEG_APCC_KENBOX_2	0.7523
p.R1517H	SIDM00121	T-Lymphoblastic Leukemia	GDSC	RKENI	DEG_APCC_KENBOX_2	0.1944
p.R1517H	ACH-000608	Ovarian Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	0.1944
p.R1517H	ACH-001738	Leukemia	CCLE	RKENI	DEG_APCC_KENBOX_2	0.1944
p.R1517H	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	RKENI	DEG_APCC_KENBOX_2	0.1944
p.P1521S	SIDM01064	Hodgkin's Lymphoma	GDSC	RKENI	DEG_APCC_KENBOX_2	0.0833
p.P1521S	ACH-000267	Lymphoma	CCLE	RKENI	DEG_APCC_KENBOX_2	0.0833
p.P1521S	HDLM-2	haematopoietic_and_lymphoid_tissue	COSMIC	RKENI	DEG_APCC_KENBOX_2	0.0833
p.R1503C	SIDM00451	T-Lymphoblastic Leukemia	GDSC	RKENI	DEG_APCC_KENBOX_2	0.1944
p.R1503C	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	RKENI	DEG_APCC_KENBOX_2	0.1944
p.E1510K	SIDM01059	Melanoma	GDSC	RKENI	DEG_APCC_KENBOX_2	0.7022
p.E1510K	ACH-000915	Skin Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	0.7022
p.E1510K	IPC-298	skin	COSMIC	RKENI	DEG_APCC_KENBOX_2	0.7022
p.K1509T	ACH-001001	Bone Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	0.7306
p.T1522K	ACH-001611	Brain Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	0.5
p.R1519Q	ACH-001863	Bile Duct Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43166	Signal-induced proliferation-associated 1-like protein 1	DEG_APCC_KENBOX_2	86:90	RKENI	APC,CDC20,FZR1	0.9334	More...
Q4LE39	AT-rich interactive domain-containing protein 4B	DEG_APCC_KENBOX_2	461:465	RKENI	APC,CDC20,FZR1	0.9638	More...
Q5T5P2	Sickle tail protein homolog	DEG_APCC_KENBOX_2	1075:1079	RKENI	APC,CDC20,FZR1	0.9909	More...
Q8N7X0	Androglobin	DEG_APCC_KENBOX_2	1508:1512	RKENI	APC,CDC20,FZR1	0.8902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RKENI

Degron related mutations and impact score

Drug responses associated with ADGB mutations

All proteins holding degron of RKENI