DegronMD - Q9Y6C5(PTCH2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N1192H	TCGA-A5-A0VQ	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	1186:1190	Mutation rewiring degron network	0.2778
p.N1192H	DO42113	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	1186:1190	Mutation rewiring degron network	0.2778
p.Q242H	TCGA-AA-3811	COAD	TCGA	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.1111
p.Q242H	DO7962	COAD	ICGC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.1111
p.Q24H	TCGA-B5-A1MX	UCEC	TCGA	PPSY	ITCH	11:14	Mutation rewiring degron network	0.0556
p.Q24H	DO41999	UCEC	ICGC	PPSY	ITCH	11:14	Mutation rewiring degron network	0.0556
p.V243A	TCGA-D1-A1O7	UCEC	TCGA	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.1389
p.V243A	DO41139	UCEC	ICGC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.1389
p.E1180D	TCGA-D3-A2JP	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	1186:1190	Mutation rewiring degron network	0.1667
p.E1180D	DO47407	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	1186:1190	Mutation rewiring degron network	0.1667
p.P5Q	TCGA-D8-A73X	BRCA	TCGA	PPSY	ITCH	11:14	Mutation blocking phosphorylation signal	0.6111
p.P5Q	DO219633	BRCA	ICGC	PPSY	ITCH	11:14	Mutation blocking phosphorylation signal	0.6111
p.P255T	TCGA-DK-A2I1	BLCA	TCGA	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation altering degron motif	0.5919
p.P255T	TCGA-EE-A2M6	SKCM	TCGA	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation altering degron motif	0.5919
p.P255T	DO444	BLCA	ICGC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation altering degron motif	0.5919
p.P255T	DO37976	SKCM	ICGC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation altering degron motif	0.5919
p.P261Q	TCGA-EB-A5UM	SKCM	TCGA	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.1944
p.P261Q	DO47282	SKCM	ICGC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.1944
p.S1189I	TCGA-FI-A2F4	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	1186:1190	Mutation altering degron motif	0.7341
p.S1189I	DO43434	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	1186:1190	Mutation altering degron motif	0.7341
p.P1178S	TCGA-YD-A9TA	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	1186:1190	Mutation rewiring degron network	0.1111
p.P1178S	DO219503	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	1186:1190	Mutation rewiring degron network	0.1111
p.R250W	DO483	BLCA	ICGC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation altering degron motif	0.8634
p.P265A	DO52432	COCA	ICGC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.0833
p.G1197R	DO228947	LICA	ICGC	AATSS	DEG_SPOP_SBC_1	1186:1190	Mutation rewiring degron network	0.1389
p.S1189R	DO229019	LICA	ICGC	AATSS	DEG_SPOP_SBC_1	1186:1190	Mutation altering degron motif	0.7427
p.T15K	DO229025	LICA	ICGC	PPSY	ITCH	11:14	Mutation blocking phosphorylation signal	0.75
p.P255H	DO229037	LICA	ICGC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation altering degron motif	0.6583
p.L258I	DO229009	LICA	ICGC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.2778
p.P12S	DO220899	MELA	ICGC	PPSY	ITCH	11:14	Mutation altering degron motif	0.6752
p.A1187G	DO229221	THCA	ICGC	AATSS	DEG_SPOP_SBC_1	1186:1190	Mutation altering degron motif	0.6429
p.A241V	SIDM02021	Esophageal Carcinoma	GDSC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.0833
p.H259Y	SIDM01004	Chronic Myelogenous Leukemia	GDSC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.25
p.H259Y	ACH-000983	Leukemia	CCLE	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.25
p.H259Y	KCL-22	haematopoietic and lymphoid tissue	COSMIC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.25
p.A264T	SIDM00781	Colorectal Carcinoma	GDSC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.1111
p.A264T	SIDM00780	Colorectal Carcinoma	GDSC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.1111
p.A264T	ACH-000967	Colon/Colorectal Cancer	CCLE	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.1111
p.A264T	ACH-001199	Colon/Colorectal Cancer	CCLE	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.1111
p.A264T	SNU-C2B	large intestine	COSMIC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.1111
p.Q245H	SIDM00953	Small Cell Lung Carcinoma	GDSC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.1944
p.P6L	SIDM00007	Other Solid Cancers	GDSC	PPSY	ITCH	11:14	Mutation rewiring degron network	0.1944
p.P6L	ACH-001550	Skin Cancer	CCLE	PPSY	ITCH	11:14	Mutation rewiring degron network	0.1944
p.T1188I	SIDM01114	Non-Cancerous	GDSC	AATSS	DEG_SPOP_SBC_1	1186:1190	Mutation altering degron motif	0.7078
p.T1188I	ACH-001383	Prostate Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	1186:1190	Mutation altering degron motif	0.7078
p.T1188I	PWR-1E	prostate	COSMIC	AATSS	DEG_SPOP_SBC_1	1186:1190	Mutation altering degron motif	0.7078

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTCH2

UniProt ID: Q9Y6C5

Entrez ID: 8643

Protein name: Protein patched homolog 2 (PTC2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTCH2 in