DegronMD

Uniprot ID: Q9Y6C5

Source protein: Protein patched homolog 2

Source gene: PTCH2

Class: LIG_APCC_ABBAyCdc20_2

Location: 250:256

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6296

ASA_SCORE: 35.7

COIL: 0.8196

CONS_SCORE: 0.4817

DSS_SCORE: 0.3345

HELIX: 0.0549

FCONS_SCORE: 1.149

RIG_SCORE: 0.7011

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q242H	TCGA-AA-3811	COAD	TCGA	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q242H	DO7962	COAD	ICGC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.V243A	TCGA-D1-A1O7	UCEC	TCGA	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.V243A	DO41139	UCEC	ICGC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.P255T	TCGA-DK-A2I1	BLCA	TCGA	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.5919
p.P255T	TCGA-EE-A2M6	SKCM	TCGA	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.5919
p.P255T	DO444	BLCA	ICGC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.5919
p.P255T	DO37976	SKCM	ICGC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.5919
p.P261Q	TCGA-EB-A5UM	SKCM	TCGA	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.P261Q	DO47282	SKCM	ICGC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R250W	DO483	BLCA	ICGC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.8634
p.P265A	DO52432	COCA	ICGC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.P255H	DO229037	LICA	ICGC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.6583
p.L258I	DO229009	LICA	ICGC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.A241V	SIDM02021	Esophageal Carcinoma	GDSC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.H259Y	SIDM01004	Chronic Myelogenous Leukemia	GDSC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.25
p.H259Y	ACH-000983	Leukemia	CCLE	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.25
p.H259Y	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.25
p.A264T	SIDM00781	Colorectal Carcinoma	GDSC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.A264T	SIDM00780	Colorectal Carcinoma	GDSC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.A264T	ACH-000967	Colon/Colorectal Cancer	CCLE	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.A264T	ACH-001199	Colon/Colorectal Cancer	CCLE	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.A264T	SNU-C2B	large_intestine	COSMIC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q245H	SIDM00953	Small Cell Lung Carcinoma	GDSC	RPCLHPD	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6C5	Protein patched homolog 2	LIG_APCC_ABBAyCdc20_2	250:256	RPCLHPD	APC,CDC20,FZR1	0.6296	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RPCLHPD

Degron related mutations and impact score

Drug responses associated with PTCH2 mutations

All proteins holding degron of RPCLHPD