DegronMD - Q02447(SP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D344N	TCGA-A8-A08H	BRCA	TCGA	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.0833
p.T342M	TCGA-B5-A3FC	UCEC	TCGA	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1389
p.Q128H	TCGA-R6-A6KZ	ESCA	TCGA	AATSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2222
p.A342T	DO228627	GACA	ICGC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1389
p.G517E	DO11076	GBM	ICGC	AFTST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1111
p.N130H	DO22839	LIHC	ICGC	AATSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2778
p.H507R	DO230530	LUSC	ICGC	AFTST	DEG_SPOP_SBC_1	505:509	Mutation altering degron motif	0.8244
p.E334D	DO46862	RECA	ICGC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation altering degron motif	0.6758
p.E334D	S-117	soft tissue	COSMIC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation altering degron motif	0.6758
p.E334D	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation altering degron motif	0.6758
p.E334D	Daudi	haematopoietic and lymphoid tissue	COSMIC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation altering degron motif	0.6758
p.T502I	DO37406	SKCM	ICGC	AFTST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.25
p.G122D	DO41133	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.G127E	DO41331	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1944
p.A501V	SIDM01307	Colorectal Carcinoma	GDSC	AFTST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.2222
p.T325A	SIDM00845	Burkitt's Lymphoma	GDSC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.T325A	SIDM00035	Thyroid Gland Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.T325A	SIDM00461	Acute Myeloid Leukemia	GDSC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.T325A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.T325A	SIDM01519	Head and Neck Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.T325A	ACH-000037	Sarcoma	CCLE	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.T325A	ACH-000786	Lymphoma	CCLE	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.T325A	ACH-000992	Head and Neck Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.T325A	ACH-001067	Brain Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.T325A	DND-41	haematopoietic and lymphoid tissue	COSMIC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.T325A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.T325A	Daudi	haematopoietic and lymphoid tissue	COSMIC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.T325A	S-117	soft tissue	COSMIC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.S131G	SIDM00845	Burkitt's Lymphoma	GDSC	AATSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.S131G	SIDM00035	Thyroid Gland Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.S131G	SIDM00461	Acute Myeloid Leukemia	GDSC	AATSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.S131G	SIDM01519	Head and Neck Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.S131G	ACH-000786	Lymphoma	CCLE	AATSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.S131G	ACH-000992	Head and Neck Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.S131G	Daudi	haematopoietic and lymphoid tissue	COSMIC	AATSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.T323S	SIDM01171	Glioblastoma	GDSC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1111
p.T323S	SIDM00311	Mesothelioma	GDSC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1111
p.T323S	SIDM01746	Osteosarcoma	GDSC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1111
p.V140A	SIDM00837	Colorectal Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2222
p.V140A	ACH-000958	Colon/Colorectal Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2222
p.V140A	SW48	large intestine	COSMIC	AATSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2222
p.V341A	SIDM00118	Colorectal Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.V341A	ACH-001081	Colon/Colorectal Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.V341A	HCC2998	large intestine	COSMIC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.I343T	SIDM00150	Colorectal Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1111
p.I343T	ACH-000969	Colon/Colorectal Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1111
p.I343T	KM12	large intestine	COSMIC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1111
p.P140L	BB30-HNC	upper aerodigestive tract	COSMIC	AATSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2222
p.A323T	SNU-81	large intestine	COSMIC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1111
p.D518G	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	AFTST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.0833
p.S321C	EFM-192A	breast	COSMIC	VPTSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.0556
p.S133N	Daudi	haematopoietic and lymphoid tissue	COSMIC	AATSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7069

Kaplan plot for SP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SP3

UniProt ID: Q02447

Entrez ID: 6670

Protein name: Transcription factor Sp3 (SPR-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SP3 in