DegronMD

Uniprot ID: Q02447

Source protein: Transcription factor Sp3

Source gene: SP3

Class: DEG_SPOP_SBC_1

Location: 505:509

E3 ligase: SPOP

DEGRON score: 0.982

ASA_SCORE: 72.28

COIL: 0.7628

CONS_SCORE: 0.2877

DSS_SCORE: 0.2793

HELIX: 0.0196

FCONS_SCORE: 0.83

RIG_SCORE: 0.7505

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G517E	DO11076	GBM	ICGC	AFTST	DEG_SPOP_SBC_1	0.1111
p.H507R	DO230530	LUSC	ICGC	AFTST	DEG_SPOP_SBC_1	0.8244
p.T502I	DO37406	SKCM	ICGC	AFTST	DEG_SPOP_SBC_1	0.25
p.A501V	SIDM01307	Colorectal Carcinoma	GDSC	AFTST	DEG_SPOP_SBC_1	0.2222
p.D518G	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	AFTST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_SPOP_SBC_1	398:402	AFTST	SPOP	0.9989	More...
Q02447	Transcription factor Sp3	DEG_SPOP_SBC_1	505:509	AFTST	SPOP	0.982	More...
Q8IYS2	Uncharacterized protein KIAA2013	DEG_SPOP_SBC_1	231:235	AFTST	SPOP	0.6933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons