DegronMD

Uniprot ID: Q8IYS2

Source protein: Uncharacterized protein KIAA2013

Source gene: KIAA2013

Class: DEG_SPOP_SBC_1

Location: 231:235

E3 ligase: SPOP

DEGRON score: 0.6933

ASA_SCORE: 61

COIL: 0.566

CONS_SCORE: 0.3477

DSS_SCORE: 0.5162

HELIX: 0.1096

FCONS_SCORE: 1.0611

RIG_SCORE: 0.7629

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G222W	TCGA-FS-A1ZC	SKCM	TCGA	AFTST	DEG_SPOP_SBC_1	0.0833
p.G222W	DO37487	SKCM	ICGC	AFTST	DEG_SPOP_SBC_1	0.0833
p.P229S	DO222542	MELA	ICGC	AFTST	DEG_SPOP_SBC_1	0.2778
p.T233S	SIDM00611	Kidney Carcinoma	GDSC	AFTST	DEG_SPOP_SBC_1	0.6005
p.T233S	SIDM00239	Kidney Carcinoma	GDSC	AFTST	DEG_SPOP_SBC_1	0.6005
p.T233S	SIDM00580	Acute Myeloid Leukemia	GDSC	AFTST	DEG_SPOP_SBC_1	0.6005
p.T233S	SIDM00018	Acute Myeloid Leukemia	GDSC	AFTST	DEG_SPOP_SBC_1	0.6005
p.T233S	SIDM01033	Bladder Carcinoma	GDSC	AFTST	DEG_SPOP_SBC_1	0.6005
p.T233S	SIDM01336	Glioblastoma	GDSC	AFTST	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_SPOP_SBC_1	398:402	AFTST	SPOP	0.9989	More...
Q02447	Transcription factor Sp3	DEG_SPOP_SBC_1	505:509	AFTST	SPOP	0.982	More...
Q8IYS2	Uncharacterized protein KIAA2013	DEG_SPOP_SBC_1	231:235	AFTST	SPOP	0.6933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons