DegronMD

Uniprot ID: O60292

Source protein: Signal-induced proliferation-associated 1-like protein 3

Source gene: SIPA1L3

Class: DEG_SPOP_SBC_1

Location: 398:402

E3 ligase: SPOP

DEGRON score: 0.9989

ASA_SCORE: 55.46

COIL: 0.7122

CONS_SCORE: 0.3663

DSS_SCORE: 0.382

HELIX: 0.228

FCONS_SCORE: 1.0182

RIG_SCORE: 0.7251

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R388L	DO936	BOCA	ICGC	AFTST	DEG_SPOP_SBC_1	0.0556
p.G394D	DO227646	COCA	ICGC	AFTST	DEG_SPOP_SBC_1	0.2222
p.G393R	DO233088	GACA	ICGC	AFTST	DEG_SPOP_SBC_1	0.1944
p.G393R	SIDM00024	Non-Cancerous	GDSC	AFTST	DEG_SPOP_SBC_1	0.1944
p.G393R	ACH-001699	Head and Neck Cancer	CCLE	AFTST	DEG_SPOP_SBC_1	0.1944
p.P397T	ACH-001057	Lymphoma	CCLE	AFTST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_SPOP_SBC_1	398:402	AFTST	SPOP	0.9989	More...
Q02447	Transcription factor Sp3	DEG_SPOP_SBC_1	505:509	AFTST	SPOP	0.982	More...
Q8IYS2	Uncharacterized protein KIAA2013	DEG_SPOP_SBC_1	231:235	AFTST	SPOP	0.6933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons