DegronMD

Uniprot ID: Q02447

Source protein: Transcription factor Sp3

Source gene: SP3

Class: DEG_SPOP_SBC_1

Location: 331:335

E3 ligase: SPOP

DEGRON score: 0.9924

ASA_SCORE: 81.56

COIL: 0.8184

CONS_SCORE: 0.2996

DSS_SCORE: 0.5657

HELIX: 0.0322

FCONS_SCORE: 0.9446

RIG_SCORE: 0.7292

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D344N	TCGA-A8-A08H	BRCA	TCGA	VPTSS	DEG_SPOP_SBC_1	0.0833
p.T342M	TCGA-B5-A3FC	UCEC	TCGA	VPTSS	DEG_SPOP_SBC_1	0.1389
p.A342T	DO228627	GACA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.1389
p.E334D	DO46862	RECA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.6758
p.E334D	S-117	soft_tissue	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.6758
p.E334D	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.6758
p.E334D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.6758
p.T325A	SIDM00845	Burkitt's Lymphoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.T325A	SIDM00035	Thyroid Gland Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.T325A	SIDM00461	Acute Myeloid Leukemia	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.T325A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.T325A	SIDM01519	Head and Neck Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.T325A	ACH-000037	Sarcoma	CCLE	VPTSS	DEG_SPOP_SBC_1	0.1667
p.T325A	ACH-000786	Lymphoma	CCLE	VPTSS	DEG_SPOP_SBC_1	0.1667
p.T325A	ACH-000992	Head and Neck Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	0.1667
p.T325A	ACH-001067	Brain Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	0.1667
p.T325A	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.T325A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.T325A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.T325A	S-117	soft_tissue	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.T323S	SIDM01171	Glioblastoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1111
p.T323S	SIDM00311	Mesothelioma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1111
p.T323S	SIDM01746	Osteosarcoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1111
p.V341A	SIDM00118	Colorectal Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.V341A	ACH-001081	Colon/Colorectal Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	0.1667
p.V341A	HCC2998	large_intestine	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.I343T	SIDM00150	Colorectal Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1111
p.I343T	ACH-000969	Colon/Colorectal Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	0.1111
p.I343T	KM12	large_intestine	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.1111
p.A323T	SNU-81	large_intestine	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.1111
p.S321C	EFM-192A	breast	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75038	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2	DEG_SPOP_SBC_1	1022:1026	VPTSS	SPOP	0.7337	More...
O75604	Ubiquitin carboxyl-terminal hydrolase 2	DEG_SPOP_SBC_1	54:58	VPTSS	SPOP	0.9881	More...
O94850	Dendrin	DEG_SPOP_SBC_1	251:255	VPTSS	SPOP	0.9712	More...
P22307	Sterol carrier protein 2	DEG_SPOP_SBC_1	422:426	VPTSS	SPOP	0.6008	More...
P31629	Transcription factor HIVEP2	DEG_SPOP_SBC_1	546:550	VPTSS	SPOP	0.9975	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2863:2867	VPTSS	SPOP	0.9646	More...
Q01973	Inactive tyrosine-protein kinase transmembrane receptor ROR1	DEG_SPOP_SBC_1	41:45	VPTSS	SPOP	0.8246	More...
Q02447	Transcription factor Sp3	DEG_SPOP_SBC_1	331:335	VPTSS	SPOP	0.9924	More...
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	471:475	VPTSS	SPOP	0.9372	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12511:12515	VPTSS	SPOP	0.96	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12667:12671	VPTSS	SPOP	0.9914	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1602:1606	VPTSS	SPOP	0.9498	More...
P60413	Keratin-associated protein 10-12	DEG_SPOP_SBC_1	216:220	VPTSS	SPOP	0.7395	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	927:931	VPTSS	SPOP	0.8818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPTSS

Degron related mutations and impact score

Drug responses associated with SP3 mutations

All proteins holding degron of VPTSS