DegronMD - P60413(KRTAP10-12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R207H	TCGA-12-3646	GBM	TCGA	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.0833
p.R207H	DO12184	GBM	ICGC	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.0833
p.R207C	TCGA-DU-5849	LGG	TCGA	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.0833
p.R207C	DO22270	LGG	ICGC	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.0833
p.R208H	TCGA-IB-7651	PAAD	TCGA	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1111
p.R208H	DO46657	PAAD	ICGC	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1111
p.G226S	DO227999	COCA	ICGC	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1667
p.G226S	DO229003	COCA	ICGC	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1667
p.G226S	DO230659	LAML	ICGC	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1667
p.G226S	DO231140	LAML	ICGC	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1667
p.G226S	DO228947	LICA	ICGC	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1667
p.G226S	DO230550	LUSC	ICGC	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1667
p.T218P	DO46478	OV	ICGC	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation altering degron motif	0.7031
p.R208C	SIDM00803	Kidney Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1111
p.R208C	769-P	kidney	COSMIC	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1111
p.R227L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1389
p.R227L	ACH-000878	Lung Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1389
p.R227L	HCC-15	lung	COSMIC	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1389
p.L228Q	SIDM01608	Endometrial Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1111
p.L228Q	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1111
p.L228Q	ACH-000553	Lung Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1111
p.L228Q	ACH-000990	Endometrial/Uterine Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1111
p.P223S	ACH-001450	Lymphoma	CCLE	VPTSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.25

Kaplan plot for KRTAP10-12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRTAP10-12

UniProt ID: P60413

Entrez ID: 386685

Protein name: Keratin-associated protein 10-12 (High sulfur keratin-associated protein 10.12) (Keratin-associated protein 10.12) (Keratin-associated protein 18-12) (Keratin-associated protein 18.12)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRTAP10-12 in