DegronMD - O75604(USP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y66C	TCGA-BR-A4CS	STAD	TCGA	VPTSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.1111
p.Y66C	DO47965	STAD	ICGC	VPTSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.1111
p.R64S	TCGA-CC-A8HV	LIHC	TCGA	VPTSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.1667
p.R64S	DO52189	LIHC	ICGC	VPTSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.1667
p.T61A	TCGA-VQ-A8PX	STAD	TCGA	VPTSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.25
p.T61A	DO51778	STAD	ICGC	VPTSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.25
p.E45Q	DO22804	LICA	ICGC	VPTSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.0833
p.R49K	DO219121	LUSC	ICGC	VPTSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.1944
p.P53L	SIDM01112	Osteosarcoma	GDSC	VPTSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.3056
p.P53L	SIDM00863	Burkitt's Lymphoma	GDSC	VPTSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.3056
p.R62H	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.2222
p.R62H	ACH-000980	Lung Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.2222
p.R62H	NCI-H1155	lung	COSMIC	VPTSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.2222
p.G67R	SIDM00276	Biliary Tract Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.0833
p.G67R	ETK-1	biliary tract	COSMIC	VPTSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.0833
p.F59V	ACH-000993	Endometrial/Uterine Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.3056

Kaplan plot for USP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP2

UniProt ID: O75604

Entrez ID: 9099

Protein name: Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP2 in