DegronMD - O94850(DDN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W193C	TCGA-50-5930	LUAD	TCGA	PPSY	ITCH	200:203	Mutation rewiring degron network	0.1389
p.W193C	DO25189	LUAD	ICGC	PPSY	ITCH	200:203	Mutation rewiring degron network	0.1389
p.R197W	TCGA-56-8622	LUSC	TCGA	PPSY	ITCH	200:203	Mutation rewiring degron network	0.25
p.R197W	DO50090	COAD	ICGC	PPSY	ITCH	200:203	Mutation rewiring degron network	0.25
p.R197W	DO45449	LUSC	ICGC	PPSY	ITCH	200:203	Mutation rewiring degron network	0.25
p.Y233C	TCGA-AJ-A5DW	UCEC	TCGA	PPSY	ITCH	230:233	Mutation altering degron motif	0.7087
p.Y233C	DO50075	UCEC	ICGC	PPSY	ITCH	230:233	Mutation altering degron motif	0.7087
p.A262V	TCGA-CD-A4MJ	STAD	TCGA	PAATPART	DEG_SCF_FBW7_1	257:264	Mutation altering degron motif	0.5825
p.A262V	DO47811	STAD	ICGC	PAATPART	DEG_SCF_FBW7_1	257:264	Mutation altering degron motif	0.5825
p.A262T	TCGA-CM-6170	COAD	TCGA	PAATPART	DEG_SCF_FBW7_1	257:264	Mutation altering degron motif	0.6028
p.A262T	DO7849	COAD	ICGC	PAATPART	DEG_SCF_FBW7_1	257:264	Mutation altering degron motif	0.6028
p.D265N	TCGA-CN-4723	HNSC	TCGA	PAATPART	DEG_SCF_FBW7_1	257:264	Mutation rewiring degron network	0.3056
p.D265N	TCGA-CN-4723	HNSC	TCGA	VPTSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.0556
p.D265N	DO14830	HNSC	ICGC	PAATPART	DEG_SCF_FBW7_1	257:264	Mutation rewiring degron network	0.3056
p.D265N	DO14830	HNSC	ICGC	VPTSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.0556
p.P201S	TCGA-EE-A29L	SKCM	TCGA	PPSY	ITCH	200:203	Mutation altering degron motif	0.6752
p.P201S	DO37835	SKCM	ICGC	PPSY	ITCH	200:203	Mutation altering degron motif	0.6752
p.P217T	TCGA-EE-A2MM	SKCM	TCGA	PPPY	ITCH	224:227	Mutation rewiring degron network	0.1389
p.P217T	DO37770	SKCM	ICGC	PPPY	ITCH	224:227	Mutation rewiring degron network	0.1389
p.G199W	TCGA-EM-A3FQ	THCA	TCGA	PPSY	ITCH	200:203	Mutation rewiring degron network	0.3056
p.G199W	TCGA-ER-A19F	SKCM	TCGA	PPSY	ITCH	200:203	Mutation rewiring degron network	0.3056
p.G199W	DO37679	SKCM	ICGC	PPSY	ITCH	200:203	Mutation rewiring degron network	0.3056
p.G199W	DO39534	THCA	ICGC	PPSY	ITCH	200:203	Mutation rewiring degron network	0.3056
p.W221L	TCGA-ER-A1A1	SKCM	TCGA	PPPY	ITCH	224:227	Mutation rewiring degron network	0.25
p.W221L	TCGA-ER-A1A1	SKCM	TCGA	PPSY	ITCH	230:233	Mutation rewiring degron network	0.0833
p.W221L	DO37413	SKCM	ICGC	PPPY	ITCH	224:227	Mutation rewiring degron network	0.25
p.W221L	DO37413	SKCM	ICGC	PPSY	ITCH	230:233	Mutation rewiring degron network	0.0833
p.P192L	TCGA-IB-7651	PAAD	TCGA	PPSY	ITCH	200:203	Mutation rewiring degron network	0.1111
p.P192L	DO46657	PAAD	ICGC	PPSY	ITCH	200:203	Mutation rewiring degron network	0.1111
p.R218Q	TCGA-N7-A4Y0	UCS	TCGA	PPPY	ITCH	224:227	Mutation rewiring degron network	0.1667
p.R218Q	SIDM01148	Plasma Cell Myeloma	GDSC	PPPY	ITCH	224:227	Mutation rewiring degron network	0.1667
p.R218Q	ACH-000050	Myeloma	CCLE	PPPY	ITCH	224:227	Mutation rewiring degron network	0.1667
p.R218Q	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	224:227	Mutation rewiring degron network	0.1667
p.R210T	TCGA-RS-A6TP	HNSC	TCGA	PPSY	ITCH	200:203	Mutation rewiring degron network	0.1389
p.R210T	DO219062	HNSC	ICGC	PPSY	ITCH	200:203	Mutation rewiring degron network	0.1389
p.G194E	DO222445	BTCA	ICGC	PPSY	ITCH	200:203	Mutation rewiring degron network	0.1667
p.R219H	DO233111	GACA	ICGC	PPPY	ITCH	224:227	Mutation rewiring degron network	0.1944
p.D265E	DO229041	LICA	ICGC	PAATPART	DEG_SCF_FBW7_1	257:264	Mutation rewiring degron network	0.3056
p.D265E	DO229041	LICA	ICGC	VPTSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.0556
p.PP200PS	DO222599	MELA	ICGC	PPSY	ITCH	200:203	Mutation altering degron motif	0.6752
p.T239S	DO232761	PBCA	ICGC	PPSY	ITCH	230:233	Mutation rewiring degron network	0.1667
p.R272S	DO229509	PRAD	ICGC	PAATPART	DEG_SCF_FBW7_1	257:264	Mutation rewiring degron network	0.1111
p.R272S	SIDM01706	Hodgkin's Lymphoma	GDSC	PAATPART	DEG_SCF_FBW7_1	257:264	Mutation rewiring degron network	0.1111
p.R272S	ACH-001093	Non-Cancerous	CCLE	PAATPART	DEG_SCF_FBW7_1	257:264	Mutation rewiring degron network	0.1111
p.T215A	DO36556	READ	ICGC	PPPY	ITCH	224:227	Mutation blocking phosphorylation signal	0.5278
p.G195S	DO219878	SKCA	ICGC	PPSY	ITCH	200:203	Mutation rewiring degron network	0.1944
p.G235C	SIDM01314	Colorectal Carcinoma	GDSC	PPPY	ITCH	224:227	Mutation rewiring degron network	0.1111
p.G235C	SIDM01314	Colorectal Carcinoma	GDSC	PPSY	ITCH	230:233	Mutation rewiring degron network	0.2778
p.R238M	SIDM00251	Gastric Carcinoma	GDSC	PPSY	ITCH	230:233	Mutation rewiring degron network	0.1944
p.R238M	ACH-000949	Gastric Cancer	CCLE	PPSY	ITCH	230:233	Mutation rewiring degron network	0.1944
p.R238M	TGBC11TKB	stomach	COSMIC	PPSY	ITCH	230:233	Mutation rewiring degron network	0.1944
p.R244T	SIDM00920	Breast Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.1389
p.R244T	ACH-000783	Breast Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.1389
p.R244T	CAMA-1	breast	COSMIC	VPTSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DDN

UniProt ID: O94850

Entrez ID: 23109

Protein name: Dendrin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DDN in