DegronMD

Uniprot ID: O94850

Source protein: Dendrin

Source gene: DDN

Class: ITCH

Location: 200:203

E3 ligase: ITCH,NEDD4

DEGRON score: 0.8751

ASA_SCORE: 87.2

COIL: 0.8498

CONS_SCORE: 1

DSS_SCORE: 0.5515

HELIX: 0.1295

FCONS_SCORE: 1.0318

RIG_SCORE: 0.6008

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P201S	TCGA-EE-A29L	SKCM	TCGA	PPSY	ITCH	0.6752
p.P201S	DO37835	SKCM	ICGC	PPSY	ITCH	0.6752
p.PP200PS	DO222599	MELA	ICGC	PPSY	ITCH	0.6752
p.G199W	TCGA-EM-A3FQ	THCA	TCGA	PPSY	ITCH	0.3056
p.G199W	TCGA-ER-A19F	SKCM	TCGA	PPSY	ITCH	0.3056
p.G199W	DO37679	SKCM	ICGC	PPSY	ITCH	0.3056
p.G199W	DO39534	THCA	ICGC	PPSY	ITCH	0.3056
p.R197W	TCGA-56-8622	LUSC	TCGA	PPSY	ITCH	0.25
p.R197W	DO50090	COAD	ICGC	PPSY	ITCH	0.25
p.R197W	DO45449	LUSC	ICGC	PPSY	ITCH	0.25
p.G195S	DO219878	SKCA	ICGC	PPSY	ITCH	0.1944
p.G194E	DO222445	BTCA	ICGC	PPSY	ITCH	0.1667
p.W193C	TCGA-50-5930	LUAD	TCGA	PPSY	ITCH	0.1389
p.W193C	DO25189	LUAD	ICGC	PPSY	ITCH	0.1389
p.R210T	TCGA-RS-A6TP	HNSC	TCGA	PPSY	ITCH	0.1389
p.R210T	DO219062	HNSC	ICGC	PPSY	ITCH	0.1389
p.P192L	TCGA-IB-7651	PAAD	TCGA	PPSY	ITCH	0.1111
p.P192L	DO46657	PAAD	ICGC	PPSY	ITCH	0.1111

Showing 1 to 18 of 18 entries

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Drug responses associated with DDN mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPSY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5R6	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein	ITCH	587:590	PPSY	ITCH,NEDD4	0.737	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	ITCH	459:462	PPSY	ITCH,NEDD4	0.9751	More...
Q8N5I2	Arrestin domain-containing protein 1	ITCH	415:418	PPSY	ITCH,NEDD4	0.9903	More...
Q96B67	Arrestin domain-containing protein 3	ITCH	346:349	PPSY	ITCH,NEDD4	0.77	More...
Q96J65	ATP-binding cassette sub-family C member 12	ITCH	420:423	PPSY	ITCH,NEDD4	0.6228	More...
Q8N2M8	CLK4-associating serine/arginine rich protein	ITCH	286:289	PPSY	ITCH,NEDD4	0.9968	More...
A6NKD9	Coiled-coil domain-containing protein 85C	ITCH	316:319	PPSY	ITCH,NEDD4	0.9875	More...
Q99715	Collagen alpha-1	ITCH	2574:2577	PPSY	ITCH,NEDD4	0.6822	More...
Q96EP5	DAZ-associated protein 1	ITCH	370:373	PPSY	ITCH,NEDD4	0.9278	More...
Q9H7D0	Dedicator of cytokinesis protein 5	ITCH	1438:1441	PPSY	ITCH,NEDD4	0.5355	More...
O94850	Dendrin	ITCH	200:203	PPSY	ITCH,NEDD4	0.8751	More...
O94850	Dendrin	ITCH	230:233	PPSY	ITCH,NEDD4	0.9726	More...
Q9UBP4	Dickkopf-related protein 3	ITCH	91:94	PPSY	ITCH,NEDD4	0.9656	More...
Q9Y5R6	Doublesex- and mab-3-related transcription factor 1	ITCH	296:299	PPSY	ITCH,NEDD4	0.7856	More...
P11161	E3 SUMO-protein ligase EGR2	ITCH	205:208	PPSY	ITCH,NEDD4	0.9358	More...
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	ITCH	156:159	PPSY	ITCH,NEDD4	0.9269	More...
Q9NT22	EMILIN-3	ITCH	160:163	PPSY	ITCH,NEDD4	0.9466	More...
Q9NRM1	Enamelin	ITCH	853:856	PPSY	ITCH,NEDD4	0.9682	More...
Q14511	Enhancer of filamentation 1	ITCH	109:112	PPSY	ITCH,NEDD4	0.9998	More...
Q6NXG1	Epithelial splicing regulatory protein 1	ITCH	554:557	PPSY	ITCH,NEDD4	0.6605	More...
P19235	Erythropoietin receptor	ITCH	501:504	PPSY	ITCH,NEDD4	0.9994	More...
Q53EP0	Fibronectin type III domain-containing protein 3B	ITCH	110:113	PPSY	ITCH,NEDD4	0.9629	More...
Q5HY92	Fidgetin	ITCH	401:404	PPSY	ITCH,NEDD4	0.9941	More...
Q9BQQ3	Golgi reassembly-stacking protein 1	ITCH	206:209	PPSY	ITCH,NEDD4	0.9258	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	ITCH	714:717	PPSY	ITCH,NEDD4	0.9896	More...

Showing 1 to 25 of 127 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSY

Degron related mutations and impact score

Drug responses associated with DDN mutations

All proteins holding degron of PPSY